results in total, 261 patients (119 sarcoidosis and 142 non-sarcoidosis ilds) were enrolled. the median (interquartile range) bal cd4/cd8 ratio and lymphocyte fraction were significantly higher in sarcoidosis than in non-sarcoidosis ilds: 3.88 (3.76) versus 0.88 (1.01), respectively, and 20.6 (28.3) versus 6.0 (13.7), respectively. t cell receptor γ delta, cd16+56+, cd103+, cd8+103+, and cd3+16...

  Sarcoidosis is a multisystem noncaseating granulomatous disease with a propensity for lung, eye, and skin which recently have been proposed that mycobacterium tuberculosis may contribute in its pathogenesis, and rarely involves central nervous system (CNS). Despite CD4+ lymphocytopenia, sarcoidosis by itself does not increase risk of opportunistic infections other than cryptococcosis.Nonethel...

The aim of this study was to evaluate alterations in calcium metabolism in sarcoidosis. The serum concentrations of calcium (sCa), ionized calcium (sCa2+), 1,25-dihydroxyvitamin D (s1,25(OH)2D3) and parathyroid hormone (sPTH), serum angiotensin-converting enzyme activity (sACE) and urinary excretion of calcium (uCa) were studied in 36 Japanese patients with pulmonary sarcoidosis, aged 48.1+/-15...

This article focuses on recent advances in the identification of genes and genetic polymorphisms that have been implicated in the development of human interstitial lung diseases. It focuses on the inherited mendelian diseases in which pulmonary fibrosis is part of the clinical phenotype and the genetics of familial idiopathic pulmonary fibrosis and other rare inherited interstitial lung disease...

sarcoidosis is a systemic granulomatous disorder of unidentified etiology, with a heterogeneous clinical presentation. it is characterized by a reduced delayed-type hypersensitivity to tuberculin and common antigens. the balance between th1, th17 and regulatory t(treg) cells controls t-cell proliferation and activation.the th17/treg ratio in the peripheral blood and bronchoalveolar lavage fluid...

RATIONALE Although immunomodulatory therapy has been clearly stated as an important landmark in treatment of ulcerative colitis, significantly improving the quality of life for patients with inflammatory bowel disease, there are several aspects to be considered regarding the possible side-effects of anti-TNF alpha agents. In spite of a good safety profile, biologic TNF antagonists may induce pa...