BACKGROUND Genomewide association studies have identified 10 low-penetrance loci that confer modestly increased risk for colorectal cancer (CRC). Although they underlie a significant proportion of CRC in the general population, their impact on the familial risk for CRC has yet to be formally enumerated. The aim of this study was to examine the combined contribution of the 10 variants, rs6983267...

background: although implantable cardioverter defibrillator (icd) saves the life of patients with life-threatening ventricular dysrhythmias, it causes various challenges in their life span. considering the increase in the number of icd users, more knowledge is required regarding changes in the patients’ life after device implantation. the aim of this study was description of changes in daily li...

Fuzzy support vector machines (FSVMs) are known for their excellent antinoise performance, but there is no general rule when the fuzzy membership function (FMF) is set up. A novel FSVM based on hyperbolas optimized by the quantum-inspired gravitational search algorithm (QGSH-FSVM) is proposed to handle this question. In the proposed QGSH-FSVM, the FMF is defined by two disparate hyperbolas, who...

Preterm birth is “a birth which takes place after at least 20, but less than 37, completed weeks of gestation. This includes both live births, and stillbirths” [15]. Preterm birth may cause problems such as perinatal mortality, serious neonatal morbidity and moderate to severe childhood disability. Between 6-10% of all births in Western countries are preterm and preterm deaths are the cause for...

OBJECTIVES China's economic reforms have led to millions of citizens being relocated to support infrastructure development, reduce poverty, and address ecological, disaster-related and other concerns. This study expands on previous research on the implications of relocation in China by examining the impact of rural elders' relocation on the perceived availability of emotional, instrumental, and...

familial colloid cyst of the third ventricle is very rare. this is one of the two largest families reported and the first in which all affected members are siblings. one asymptomatic sister was found by screening, emphasizing the value of screening. a brother and two sisters from a family consisting of three brothers and three sisters who were diagnosed as having colloid cyst of the third ventr...

OBJECTIVES To compare prevalence rates of weight-control behaviors among adolescents with and without chronic illness and to explore the role of familial and other social factors on associations between disordered eating and chronic illness. DESIGN AND SETTING Survey conducted in public schools in Connecticut. PARTICIPANTS A representative statewide population-based sample of 9343 7th-, 9th...

Background: Familial chylomicronemia syndrome is a rare disorder of lipoprotein metabolism due to familial lipoprotein lipase or apolipoprotein C-II deficiency or the presence of inhibitors to lipoprotein lipase. It manifests as eruptive xanthomas, acute pancreatitis, and lipaemic plasma due to marked elevation of triglyceride and chylomicrons levels. Case presentation: We report a rare case of...

abstract bachground and aim: mutation analysis of mitochondrial genome and brca genes are helpful in the early diagnosis of familial breast cancers. in this study, we investigated mitochondrial common deletion and brca mutations through multiplex pcr and clinical parameters for the detection of familial breast cancers in archival breast cancer samples. methods: the multiplex pcr was conducted o...

Characteristics of the familial and societal context were examined as predictors of Latino adolescents' (N = 323; 49.5% female) ethnic identity. Consistent with previous work, familial ethnic socialization significantly predicted future levels of ethnic identity exploration, resolution, and affirmation for both male adolescents and female adolescents, although the association was significantly ...