INTRODUCTION Rosacea is a common inflammatory disorder, characterized by a spectrum of facial manifestations. The clinical similarity to other dermatoses, like lupus erythematosus, might lead to misdiagnosis, particularly in patients with elevated antinuclear antibody titers. AIM To assess the frequency, titer and specificity of antinuclear antibodies in rosacea patients and correlate these f...

Immunofluorescent imaging has been a powerful technique in helping to identify intracellular nuclear and cytoplasmic molecules which are target antigens of autoantibodies in systemic autoimmune disorders. Patterns of staining can be correlated with molecules engaged in specific cellular functions and distributed in distinct cellular domains. Different autoimmune disorders have different profile...

Antinuclear antibodies were detected by immunofluorescence in most sera from rabbits immunized with whole human serum emulsified in Freund's complete adjuvant. Four of 14 sera from rabbits immunized with Cohn fractions III, IV-1, or IV-4 also gave positive nuclear fluorescence with human leukocyte nuclei. Other human and animal nuclei gave negative results with these rabbit antisera. Three rabb...

The prevalence of antiphospholipid and antinuclear antibodies in 102 patients with at least three unexplained miscarriages before a gestational age of 12 weeks, or at least one intrauterine fetal death after 12 weeks, was investigated and compared with the prevalence in 102 normal pregnant controls. Six patients had a history of thrombosis and six had 'lupus-like' disease. Twenty one patients h...

Both Raynaud's phenomenon and the presence of antinuclear antibodies are uncommon features of malignant disease and the association of both with a malignancy extremely rare. The case is reported of a 78 year old woman who presented with Raynaud's phenomenon and positive antinuclear antibodies related to adenocarcinoma of unknown primary site.

In addition to cellular immune responses, humoral immune responses, mediated by natural antibodies, autoantibodies, and alloantibodies, have increasingly been recognized as causes of organ transplant rejection. In our previous studies, we have demonstrated the induction of antinuclear antibodies against histone H1 and high-mobility group box 1 (HMGB1), in both experimental and clinical liver tr...

and dysmorphic red blood cell casts. A quantitative serum pregnancy test was positive. Bronchoalveolar lavage retrieved blood-tinged fluid, numerous red blood cells and hemosiderin-laden macrophages but few neutrophils. Microbiology studies for bacteria, mycobacteria and fungi in the bronchoalveolar lavage fluid were negative. Perinuclear antineutrophil cytoplasmic antibodies (P-ANCA) with spec...

and dysmorphic red blood cell casts. A quantitative serum pregnancy test was positive. Bronchoalveolar lavage retrieved blood-tinged fluid, numerous red blood cells and hemosiderin-laden macrophages but few neutrophils. Microbiology studies for bacteria, mycobacteria and fungi in the bronchoalveolar lavage fluid were negative. Perinuclear antineutrophil cytoplasmic antibodies (P-ANCA) with spec...