Lead is a ubiquitous environmental pollutant that poses serious health problems to humans, especially children. However, genetic variability in individuals varies their susceptibility lead poisoning. One possible factor polymorphism. Thus, this study aimed investigate the association between blood level (BLL), and polymorphisms delta-aminolevulinic acid dehydratase (ALAD) MspI (rs1800435) vitam...

BACKGROUND IL12A has been implicated in T-cell development and may thus influence the development of atopy and allergic diseases. METHODS We tested for association between four linkage disequilibrium (LD)-tagging SNPs (rs2243123, rs2243151, rs668998, and rs17826053) in IL12A and asthma and allergy-related (serum total and allergen-specific IgE, and skin test reactivity [STR] to two common all...

Haplotype association studies based on family genotype data can provide more biological information than single marker association studies. Difficulties arise, however, in the inference of haplotype phase determination and in haplotype transmission/non-transmission status. Incorporation of the uncertainty associated with haplotype inference into regression models requires special care. This tas...

Type 2 diabetes is a common disorder associated with obesity. Lower plasma levels of adiponectin were associated with type 2 diabetes. Candidate regions on chromosomes 1 ( approximately 70 cM) and 14 ( approximately 30 cM) were evaluated for replication of suggestive linkage results for type 2 diabetes/impaired glucose homeostasis in an independent sample of Japanese Americans. Replication of i...

Association of single nucleotide polymorphisms in the LPA gene region with serum Lp(a) levels and myocardial infarction Dissertation zur Erlangung des Doktorgrades der Naturwissenschaften (Dr. rer. Quidquid agis prudenter agas et respice finem. AA amino acid apo(a) apolipoprotein (a) asPCR allele-specific PCR BMI body mass index bp base pair CAD coronary artery disease CHD coronary heart diseas...

Quantitative trait transmission/disequilibrium tests (quantitative TDTs) are commonly used in family-based genetic association studies of quantitative traits. Despite the availability of various quantitative TDTs, some users are not aware of the properties of these tests and the relationships between them. This review aims at outlining the broad features of the various quantitative TDT procedur...

Plasmodium falciparum malaria is a major cause of morbidity and mortality in many developing countries especially in sub-Saharan Africa. A susceptibility locus for mild malaria has been mapped to the MHC region, and TNF polymorphisms have been associated with mild malaria. The Natural Cytotoxicity-triggering Receptor 3 (NCR3) gene is located in the peak region of linkage, and is 15kb distal to ...

The Framingham Heart Study dataset used for the analyses was obtained from the National Center for Biotechnology Information database of genotypes and phenotypes (NCBI dbGaP) through accession number phs000128.v3.p3. ABSTRACT Family-based study design is commonly used in genetic research. It has many ideal features, including being robust to population stratification (PS). With the advance of h...

BACKGROUND Genetic diversity of three polymorphic markers in the phenylalanine hydroxylase (PAH) gene region including PvuII (a), PAHSTR and MspI were investigated. METHODS Unrelated individuals (n=139) from the Iranian populations were genotyped using primers specific to PAH gene markers including PvuII(a), MspI and PAHSTR. The amplified products for PvuII(a), MspI were digested using the ap...

We introduce a stepwise approach for family-based designs for selecting a set of markers in a gene that are independently associated with the disease. The approach is based on testing the effect of a set of markers conditional on another set of markers. Several likelihood-based approaches have been proposed for special cases, but no model-free based tests have been proposed. We propose two type...