The relationships between the generalized directional derivative of the distance function and the existence of nearest points as well as some geometry properties in Banach spaces are studied. It is proved in the present paper that the condition that for each closed subset G of X and x ∈ X \ G, the Clarke, Michel-Penot, Dini or modified Dini directional derivative of the distance function is 1 o...

10-Formyltetrahydrofolate dehydrogenase (FDH) is composed of three domains and possesses three catalytic activities but has only two catalytic centers. The amino-terminal domain (residue 1-310) bears 10-formyltetrahydrofolate hydrolase activity, the carboxyl-terminal domain (residue 420-902) bears an aldehyde dehydrogenase activity, and the full-length FDH produces 10-formyltetrahydrofolate deh...

The ultimate goal of this research is to construct a new direct CO2 fixation system using photosystems in living algae. Here, we report light-driven formate production from CO2 by using cyanobacterial photosystem I (PS I). Formate, a chemical hydrogen carrier and important industrial material, can be produced from CO2 by using the reducing power and the catalytic function of formate dehydrogena...

BACKGROUND Enzymatic NADH or NADPH-dependent reduction is a widely applied approach for the synthesis of optically active organic compounds. The overall biocatalytic conversion usually involves in situ regeneration of the expensive NAD(P)H. Oxidation of formate to carbon dioxide, catalyzed by formate dehydrogenase (EC 1.2.1.2; FDH), presents an almost ideal process solution for coenzyme regener...

CO2 emissions are the primary reason for global warming; hence, biological and chemical technologies converting into useful compounds being actively studied. Biological methods using enzymes can convert under mild conditions. Formate dehydrogenase (FDH) is a representative conversion enzyme. Its function was revealed after isolation from bacteria, yeast, plants. In this study, we evaluated pote...

Alcoholism has been associated with folate deficiency in humans and laboratory animals. Previous study showed that ethanol feeding reduces the dehydrogenase and hydrolase activity of 10-formyltetrahydrofolate dehydrogenase (FDH) in rat liver. Hepatic ethanol metabolism generates acetaldehyde and acetate. The mechanisms by which ethanol and its metabolites produce toxicity within the liver cells...

In this paper, we address a shortest path problem where an autonomous vehicle moves on a polyhedral surface according to a distance function that depends on the direction of the movement (directional) and on the friction of the space (frictional). This shortest path problem generalizes a hierarchy of problems and finds geometric structure to solve several proximity problems. We perform the char...

Femtosecond to picosecond dynamics of enzyme active sites is relatively unknown. With the advent of two-dimension infrared spectroscopy, it is now possible to characterize thermally activated motions at this time scale in functionally relevant enzyme complexes. We present a series of measurements on complexes of formate dehydrogenase (FDH) using transitional-state analog inhibitor azide as a re...

Bankruptcy in the same amount of time and history is very rampant and therefore the vision of the future can be prevented. Using data envelopment analysis (DEA) and malmquist index can precise evaluating of the performances of many different kinds of decision making units (DMU) such as hospitals, universities, business firms, etc. In this paper, we will modify directional distance formulation o...

The efficiency measurement is a subject of great interest. The majority of studies on DEA models have been carried out using radial or non-radial approaches regarding the application of DEA for the efficiency measurement. This paper, based on the directional distance function, proposes a new generalized hybrid measure of efficiency under generalized returns to scale with the existence of both r...