AUTOMATED BRAIN EXTRACTION IN FETAL MRI BY MULTI-ATLAS FUSION STRATEGY: STUDY ON HEALTHY AND PATHOLOGICAL SUBJECTS. Sébastien Tourbier, Xavier Bresson, Patric Hagmann, Maud Cagneaux, Marie Schaer, Laurent Guibaud, Jean-Philippe Thiran, Reto Meuli, and Meritxell Bach Cuadra Centre d'Imagerie BioMédicale (CIBM), Lausanne, Vaud, Switzerland, Department of Radiology, University Hospital Center (CHU...

OBJECTIVE The relationship between placental and fetal brain growth is poorly understood and difficult to assess. The objective of this study was to interrogate placental and fetal brain growth in healthy pregnancies and those complicated by fetal growth restriction (FGR). STUDY DESIGN In a prospective, observational study, pregnant women with normal pregnancies or pregnancies complicated by ...

Most children with in utero alcohol exposure do not exhibit all features of fetal alcohol syndrome (FAS), and a challenge for clinicians is to make an early diagnosis of fetal alcohol spectrum disorders (FASD) to avoid lost opportunities for care. In brain, correct neurodevelopment requires proper angiogenesis. Since alcohol alters brain angiogenesis and the placenta is a major source of angiog...

background: silymarin is a flavonolignan that has been the subject of research to evaluate the beneficial properties for decades. silymarin has been known for its potent cytoprotective, hepatoprotective and antioxidant activities. the goal of the present study was to gain a deeper understanding of possible molecular mechanisms of apoptosis of the injuries induced by silymarin on balb/c mice fet...

Epigenetic processes play a key role in orchestrating transcriptional regulation during development. The importance of DNA methylation in fetal brain development is highlighted by the dynamic expression of de novo DNA methyltransferases during the perinatal period and neurodevelopmental deficits associated with mutations in the methyl-CpG binding protein 2 (MECP2) gene. However, our knowledge a...

Objective During labor the fetal head is subjected to pressure related to uterine contractions and maternal pushing. Here we systematically review what is known about fetal head compression and its effects on fetal intracranial pressure, oxygenation, blood flow and cerebral function, and the plausibility that it might cause isolated fetal brain injury. Study Design Systematic review of intrapar...

Analysis of the fetal heart rate during pregnancy is essential for monitoring proper development fetus. Current techniques lack accuracy in and features acquisition, resulting diagnostic medical issues. The challenge lies extraction ECG from mother pregnancy. This approach has advantage being a reliable non-invasive technique. In present paper, wavelet/multiwavelet method proposed to perfectly ...

BACKGROUND/AIMS Viral infection during pregnancy is known to affect the fetal brain. The toll-like receptor (TLR)-3 is a pattern recognition receptor activated by viruses known to elicit adverse fetal neurological outcomes. The P-glycoprotein (P-gp) efflux transporter protects the developing fetus by limiting the transfer of substrates across both the placenta and the fetal blood-brain barrier ...

UNLABELLED Cocaine abuse during pregnancy has been associated with numerous adverse perinatal outcomes. AIMS The present study was to determine whether prenatal cocaine exposure induced apoptosis and the possible role of Bcl-2 family genes in the programming cell death in fetal rat brain. MAIN METHODS Pregnant rats were treated with cocaine subcutaneously (30 & 60 mg/kg/day) from day 15 to ...

Fetal electrocardiogram (FECG) extraction has a vital role in medical diagnosis during pregnancy. In this paper, We Proposed a method for removal of background noise and artifacts from FECG signals using adaptive filters has been proposed. The proposed method uses adaptive noise cancellation and digital filters for FECG extraction. Proposed FECG extraction algorithm has been implemented in MATL...