نتایج جستجو برای: fibrillogenesis
تعداد نتایج: 604 فیلتر نتایج به سال:
Human C1q when injected directly into hippocampus and cortex of doubly transgenic APP1PS1 mice results in the increase of Congo red–positive fibrillar deposits. Although there was no significant change in overall area stained for Ab total, qualitatively it appeared that there was less diffuse Ab in C1q-treated mice versus vehicle. There was no apparent change in astroglial or microglial activat...
The functional properties of tendon require an extracellular matrix (ECM) rich in elongated collagen fibrils in parallel register. We sought to understand how embryonic fibroblasts elaborate this exquisite arrangement of fibrils. We show that procollagen processing and collagen fibrillogenesis are initiated in Golgi to plasma membrane carriers (GPCs). These carriers and their cargo of 28-nm-dia...
Mena is an Ena/VASP family actin regulator with roles in cell migration, chemotaxis, cell-cell adhesion, tumor cell invasion, and metastasis. Although enriched in focal adhesions, Mena has no established function within these structures. We find that Mena forms an adhesion-regulated complex with α5β1 integrin, a fibronectin receptor involved in cell adhesion, motility, fibronectin fibrillogenes...
Protein fibrillogenesis is a universal tool of nano-to-micro scale construction supporting different forms of biological function. Its exploitable potential in nanoscience and technology is substantial, but the direct observation of homogeneous fibre growth able to underpin a kinetic-based rationale for building customized nanostructures in situ is lacking. Here we introduce a kinetic model of ...
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