The blood and urinary fibrinolytic activities were simultaneously estimated in 14 ;normal' patients under basal conditions on successive days. No direct correlation between the fibrinolytic activities in the blood and urine was demonstrated. The origin of urokinase is discussed.

OBJECTIVE To study the effects of oestrogen replacement treatment on fibrinolytic potential in postmenopausal women. DESIGN Randomised, double blind, placebo controlled trial of oral 17 beta-oestradiol. SETTING Subjects were evaluated in the outpatient setting. PATIENTS Nineteen postmenopausal women with mild dyslipidaemia, aged 44 to 69 years (mean (SD) 55.7 (6.7)). MAIN OUTCOME MEASUR...

Recombinant variants of tissue plasminogen activator (t-PA) containing either substitutions or deletions of amino acids within the fibronectin finger-like domain (residues 6-50) were found to exhibit widely varying in vivo clearance profiles in rats and fibrinolytic activity in 125I-fibrin clot lysis assays. Clearance was not significantly affected by changes in the densely charged region of am...

OBJECTIVE Prosthetic heart valve thrombosis (PVT) is a rare but severe cardiac condition. There are only a few data regarding comparison of the fibrinolytic and surgical approaches for the treatment of PVT. In this study, we compared the results of fibrinolytic therapy versus surgery in patients who presented to our institution with a diagnosis of obstructive-type PVT. METHODS From January 20...

Prevalensi stroke terus meningkat setiap tahun. Penanganan kasus harus dilakukan sesegera mungkin untuk memaksimalkan pemulihan serta mencegah berulang. Pada iskemik akut, pengobatan fibrinolitik tPA terbukti efektif. Beberapa kriteria pemberian dipenuhi. Pasien yang mendapat observasi tekanan darah ketat dan memastikan tidak terjadi efek samping perdarahan. Hingga saat ini, hanya alteplase dis...

Fibrinolytic therapy progressed by the evolution of different strategies that helped in enhancing its efficacy and specificity. The use microbial fibrinolytic enzymes is leading to a promising direction for treatment cardiovascular diseases. Subtilisin, member subtilases enzyme abundantly found Bacillus species. isolation subtilisin gene (quaking homolog) from subtilis was attempted present wor...

The primary aim was to investigate how the oral surgical interventions, as psychophysical and operative trauma, influence the response of the blood fibrinolytic system, and whether the possible changes in the level of the activators and inhibitors of the fibrinolytic system could correlate to clini­ cal results. Fourthly healthy subjects with operative tooth extractions were included in the res...

Palm wine, known as tuak in Indonesia, is a traditional alcoholic beverage in Tapanuli region, North Sumatera that is made by fermenting the sugary sap of sugar palm tree (Arenga pinnata) and the bark of tree called raru (Vatica pauciflora Blume). In this study, we screened 4 bacterial strains from palm wine, and found that T2 strain showed potential fibrinolytic activity. Several steps of puri...

A study of fibrinolytic activity in sickle-cell patients during asymptomatic periods has shown a normal fibrinolytic response to exercise and local heat to the arm. During vasoocclusive crises there was no significant decrease in fibrinolytic activity. These results contrast with earlier reports of decreased fibrinolysis during crisis and a suggestion that fibrinolytic activators might be of va...

Fibrinolytic therapy has an expanding role in the treatment of many thromboembolic disorders. Four fibrinolytic drugs are currently marketed: streptokinase, anisoylated plasminogen-streptokinase activator complex, urokinase, and recombinant human tissue-type plasminogen activator. All 4 of these drugs activate the fibrinolytic system by converting plasminogen to the active enzyme, plasmin. Plas...