The Gin invertase of bacteriophage Mu mediates recombination between two inverted gix sites. Recombination requires the presence of a second protein, Fis, which binds to an enhancer sequence. We have isolated 24 different mutants of Gin that are impaired in DNA inversion but proficient in DNA binding. Six of these mutants could be suppressed for inversion by introduction of a second mutation, w...

The transcription factor FIS has been implicated in the regulation of several stable RNA promoters, including that for the major tRNALeu species in Escherichia coli, tRNA1Leu. However, no evidence for direct involvement of FIS in tRNA1Leu expression has been reported. We show here that FIS binds to a site upstream of the leuV promoter (centered at -71) and that it directly stimulates leuV trans...

P. multocida is the causative agent of a wide range of diseases of animals, including fowl cholera in poultry and wild birds. Fowl cholera isolates of P. multocida generally express a capsular polysaccharide composed of hyaluronic acid. There have been reports of spontaneous capsule loss in P. multocida, but the mechanism by which this occurs has not been determined. In this study, we identifie...

Performability modelling has been most successfully applied for gracefully degradable computer systems by using Markov reward models [2]. In this approach the relation of the performability model with the underlying performance and dependability model is exploited. For many systems and for many measures of interest this type of modelling is not suited, so another performability modelling approa...

Methods Patients with early RA were assessed prospectively for 12 months using high-resolution B-mode and Power Doppler (PD) ultrasound. A cumulative ultrasound score was derived to measure change in the presence of joint effusions, synovitis, erosions, PD, and tenosynovitis between baseline and 12 months. Change in scores was calculated alongside change in global disease (DAS28), disability (H...

STUDY DESIGN A hypothesis-driven study was conducted in a familial cohort to determine the potential association between variants within the TBX6 gene and Familial Idiopathic Scoliosis (FIS). OBJECTIVE To determine if variants within exons of the TBX6 gene segregate with the FIS phenotype within a sample of families with FIS. SUMMARY OF BACKGROUND DATA Idiopathic Scoliosis (IS) is a structu...

Foal immunodeficiency syndrome (FIS), a fatal autosomal recessive disease found in three breeds of horses, was first reported (in the Fell pony) in 1996, and it soon became apparent that significant numbers of syndrome foals were being born each year. In each FIS case, the foals are clinically normal at birth, but start to weaken at 2–8 weeks (Scholes and others 1998) as they develop profound a...

Terrorism has led to many problems in Thai societies, not only property damage but also civilian casualties. Predicting terrorism activities in advance can help prepare and manage risk from sabotage by these activities. This paper proposes a framework focusing on event classification in terrorism domain using fuzzy inference systems (FISs). Each FIS is a decisionmaking model combining fuzzy log...

Macro-prudential policy is concerned with mitigating system wide risks arising from negative externalities from monetary and financial activities. The need to design a Pigou tax to control systemic risk from financial intermediaries (FIs) has come to the forefront after extensive tax payer bail outs in the aftermath of the 2007 financial crisis. Holistic visualization of the financial system us...

The interaction of Crohn's disease (CD)-associated adherent-invasive Escherichia coli (AIEC) strain LF82 with intestinal epithelial cells depends on surface appendages, such as type 1 pili and flagella. Histone-like proteins operate as global regulators to control the expression of these virulence factors. We evaluated the role of histone-like proteins in AIEC reference strain LF82 during infec...