Recently, the central mTOR pathway has emerged as a clinically relevant player in pathogenesis of psoriasis. Our previous study shown that fisetin, dietary polyphenol, possesses prodifferentiation and inhibitory properties, suppresses psoriasis-like responses vitro. However, effects fisetin on psoriasis vivo underlying mechanisms are unclear. Here, we evaluated fisetin's cytokines(IL-6/22 TNF-A...

The genus Artemisia has recognized medicinal value and its use by humans Dates back to centuries ago. With the appearance of new coronavirus, end 2019, several countries have recommended herbal teas consisting mainly Artemisia. individual analysis constituents this species is crucial characterize optimize antiSARS-Cov-2 action. We evaluated molecular docking inhibitory action major compounds (A...

Alzheimer׳s disease (AD) is one of the most common dementias showing slow progressive cognitive decline. Progression of intracerebral accumulation of beta amyloid (Aβ) peptides by the action of amyloid binding alcohol dehydrogenase (ABAD), a mitochondrial enzyme and β-site amyloid precursor protein cleaving enzyme 1 (BACE1) and the degradation of Acetylcholinesterase (AChE) the main pathologica...

Melanoma is the most deadly form of cutaneous malignancy, and its incidence rates are rising worldwide. In melanoma, constitutive activation of the BRAF/MEK/ERK (MAPK) and PI3K/AKT/mTOR (PI3K) signaling pathways plays a pivotal role in cell proliferation, survival and tumorigenesis. A combination of compounds that lead to an optimal blockade of these critical signaling pathways may provide an e...

Infectious or non-infectious peritonitis leads to systemic inflammation due to violation of the peritoneum which is often fatal. Fisetin, a flavonol compound, exhibits a broad spectrum of biological activities including anti-oxidant, anti-inflammatory, anti-cancer and neuro-protective effects. It was used in a murine model of thioglycollate (TG)induced aseptic peritonitis to investigate its ant...

PURPOSE The paper tries to assess the protective effect of fisetin against •OH-induced DNA damage, then to investigate the possible mechanism. METHODS The protective effect was evaluated based on the content of malondialdehyde (MDA). The possible mechanism was analyzed using various antioxidant methods in vitro, including •OH scavenging (deoxyribose degradation), •O2 (-) scavenging (pyrogallo...

It is becoming increasingly clear that neurological diseases are multi-factorial involving disruptions in multiple cellular systems. Thus, while each disease has its own initiating mechanisms and pathologies, certain common pathways appear to be involved in most, if not all, neurological diseases. Thus, it is unlikely that modulating only a single factor will be effective at either preventing d...

Fisetin (3,7,3',4'-tetrahydroxyflavone) and quercetin (3,5,7,3',4'-pentahydroxyflavone) are the bioactive plant flavonoids that are potentially useful therapeutic drugs for the treatment of a broad spectrum of diseases, including atherosclerosis, cardiovascular disease, obesity, hypertension, and cancer. 3-Hydroxyflavone (3HF) and 7-hydroxyflavone (7HF) are the synthetic chromophores of fisetin...

Inhibition of α-glucosidase has been used as a management type 2 diabetes mellitus, where studies are focused on finding more efficacious and safe drugs. Herein, the research aimed to unveil potential phytoconstituents contained in methanol extract Muntingia calabura leaves inhibiting through molecular docking simulation. From systematic search (Scopus), we found 5 eligible articles identified ...

The overactive hypothalamic–pituitary–adrenal (HPA) axis is believed to trigger the overproduction of corticosterone, leading neurotoxicity in brain. Fisetin a flavonoid commonly found fruits and vegetables. It has been suggested possess various biological activities, including antioxidant, anti-inflammatory, neuroprotective effects. This study aims explore potential properties fisetin against ...