BACKGROUND Retroviral-mediated gene transfer stably introduces exogenous genes into normal and neoplastic cells of the hematopoietic system. METHODS We used two retroviral vectors [the first, FLac, expresses a chimeric protein (Sh-ble::LacZ) between the product of the phleomycin resistance gene (Sh-ble) and the bacterial beta-galactosidase encoded by the LacZ gene; the second, NuNL vector, co...

Back swing connections during gymnastics acrobatic series considerably influence technical performance and difficulties, particularly in the back somersault. The aim of this study was to compare the take-off's kinetic and kinematic variables between two acrobatic series leading to perform the backward stretched somersault (also called salto): round-off, flic-flac to stretched salto versus round...

The purpose of this paper is to report the first stage of the implementation within FLAC of a hydromechanical model using an iterative procedure between two independent hydraulic and mechanical sub-models. The fracture network of the rock mass is considered using the multilaminated medium concept. The implemented model is illustrated through its application to the hydraulic circuit of the Venda...

The last seismic events showed that tunnel lining may suffer extensive damage. Employing numerical modeling has a great importance in predicting the performance of tunnels. This paper tests Zaouit Ait Mellal (ZAM) twin tunnels located between cities Marrakesh and Agadir Morocco. Dynamic analysis was adopted by FLAC 2D software using finite-difference elements. Four soil cross-sections were chos...

Complex flagellar filaments are unusual in their fine structure composed of flagellin dimers, in their right-handed helicity, and in their rigidity, which prevents a switch of handedness. The complex filaments of Rhizobium lupini H13-3 and those of Sinorhizobium meliloti are composed of three and four flagellin (Fla) subunits, respectively. The Fla-encoding genes, named flaA through flaD, are s...

Cancers develop metabolic strategies to cope with their microenvironment often characterized by hypoxia, limited nutrient bioavailability and exposure to anticancer treatments. Among these strategies, the metabolic symbiosis based on the exchange of lactate between hypoxic/glycolytic cancer cells that convert glucose to lactate and oxidative cancer cells that preferentially use lactate as an ox...