OBJECTIVE c-FLIP is a natural homologue of caspase 8, and may antagonize activation of death pathways mediated by FADD. c-FLIP is highly expressed in the heart, and a recent report suggests that c-FLIP may protect against certain types of myocyte death. The present study was designed to define the expression patterns of c-FLIP in the heart. METHODS The expression pattern of c-FLIP in end-stag...

Glutamatergic transmission converging on calcium signaling plays a key role in dendritic differentiation. In early development, AMPA receptor (AMPAR) transcripts are extensively spliced and edited to generate subunits that differ in their biophysical properties. Whether these subunits have specific roles in the context of structural differentiation is unclear. We have investigated the role of n...

In this paper, we consider a general time-space discrete host-parasitoid model with the periodic boundary conditions. We analyzed and obtained some usual conditions, such as Turing instability occurrence, Flip bifurcation Neimark-Sacker occurrence. also find several multiple phenomena, 1 : 2 Resonance, Neimark-Sacker-Flip bifurcation, Neimark-Sacker-Neimark-Sacker Neimark-Sacker-Flip-Flip induc...

The logic construction of a double-edge-triggered (DET) flip-flop, which can receive input signal at two levels of the clock, is analyzed and a new circuit design of CMOS DET flip-flop is proposed. Simulation using SPICE and a 1 micron technology shows that this DET flip-flop has ideal logic functionality, a simpler structure, lower delay time and higher maximum data rate compared to other exis...

FLICE-inhibitory protein, FLIP (Casper/I-FLICE/FLAME-1/CASH/CLARP/MRIT), which contains two death effector domains and an inactive caspase domain, binds to FADD and caspase-8, and thereby inhibits death receptor-mediated apoptosis. Here, we characterize the inhibitory effect of FLIP on a variety of apoptotic pathways. Human Jurkat T cells undergoing Fas ligand-mediated apoptosis in response to ...

Power reduction has become a vital design goal for sophisticated design applications, whether mobile or not. dropping power consumption in design enables better, cheaper products to be designed and power-related chip failures to be minimized. Researchers have shown that multi-bit flip-flop is an effective method for clock power consumption reduction. The underlying idea behind multi-bit flip-fl...

New designs for Hybrid latch flip-flip (HLFF) and implicit-pulsed data-close-to-output (ip-DCO) flipflop circuits are proposed to improve the redundant switching activity, speed and power as these flip-flop circuits are basic building blocks of many timing elements. This paper evaluates and compares the performance of various flip-flop circuits which can reduce the effect of redundant switching...

A new flip-flop design using a double-pulsed static latch is presented. The flip-flop has only a single stage of logic in the critical path and as a result is up to three times faster than the fastest previously known flip-flops, while consuming approximately the same energy as the lowestpower flip-flops. The flip-flop has asymmetric timing properties which make it a good match to skewed logic ...

The antiapoptotic protein FLIP(S) is a key suppressor of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in human glioblastoma multiforme (GBM) cells. We previously reported that a novel phosphatase and tensin homologue (PTEN)-Akt-atrophin-interacting protein 4 (AIP4) pathway regulates FLIP(S) ubiquitination and stability, although the means by which PTEN and A...