The purpose of the study was to prepare and evaluate clarithromycin (CLA) floating tablets using experimental mixture design for treatment of Helicobacter pylori provided by prolonged gastric residence time and controlled plasma level. Ten different formulations were generated based on different molecular weight of hypromellose (HPMC K100, K4M, K15M) by using simplex lattice design (a sub-class...

The gastroretentive dosage forms have potential for use as controlled-release drug delivery systems. The use of floating dosage forms is one method to achieve prolonged gastric residence times, providing opportunity for both local and systemic drug action. The present investigation involve the development and in vitro evaluation of the floating matrix tablets, which after oral administration ca...

The aim of this work was to design and evaluate effervescent floating gastro-retentive drug delivery matrix tablets with sustained-release behavior using a binary mixture of hydroxyethyl cellulose and sodium alginate. Pentoxifylline was used as a highly water-soluble, short half-life model drug with a high density. The floating capacity, swelling, and drug release behaviors of drug-loaded matri...

Objective: The present study investigates the use of indomethacin–solubilizers solid dispersions for the development of controlled-release bilayer floating tablet formulations. Materials and Methods: The physical state of the dispersed indomethacin in the solubilizers mixture was characterized by Scanning electron microscopy, differential scanning calorimetry, powder X-ray diffraction, and IR s...

The aim of the present study was to apply design of experiment (DOE) to optimize floating drug delivery of tapentadol hydrochloride. Tapentadol hydrochloride is a synthetic opioid used as a centrally acting analgesic and effective in both experimental and clinical pain. The half-life of the drug is about 4 hours and oral dose is 50 to 250 mg twice a day. For optimization 3(2) full factorial des...

This paper deals with the solution bounds for time-delay systems via delay-dependent Lyapunov– Krasovskiimethods. Solution bounds arewidely used for systemswith input saturation caused by actuator saturation or by the quantizers with saturation.We show that an additional bound for solutions is needed for the first time-interval, where t < τ(t), both in the continuous and in the discrete time. T...

The present study focused on the development of gastroretentive technology which will deliver the antibiotic at predetermined rate to achieve the local concentration enough to act as antibacterial against H.Pylori. This technology ensures the maximum utilization of the drug with minimum side effects and maximum patient compliance and also with reduced antibiotic resistance by the bacterium. The...

The conversion from discrete-time to continuous-time models is sometimes quite troublesome. This paper answers related pending questions concerning z-domain poles at the origin, and relating them to s-domain models with time delay. Special attention is devoted to the tradeoff between fractional delay and direct feed-through. The paper places these questions into a general framework of model map...

In the present work, a gastroretentive in situ gelling liquid formulation for controlled delivery of ranitidine was formulated using sodium alginate (low, medium and high viscosity grades), calcium carbonate (source of cations) and ranitidine. Prepared formulations were evaluated for viscosity, buoyancy lag time and buoyancy duration, drug content and in vitro drug release. Formulation variable...