The mechanical stress due to shear flow has profound effects on cell proliferation, transport, gene expression, and apoptosis. The mechanisms for flow sensing and transduction are unclear, but it is postulated that fluid flow pulls upon the apical surface, and the resulting stress is eventually transmitted through the cytoskeleton to adhesion plaques on the basal surface. Here we report a direc...

In this investigation, a mathematical model for studying oscillatory flow of blood in a stenosed artery under the influence of transverse magnetic field through porous medium has been developed. The equations of motion of blood flow are solved analytically. The analytical expressions for axial velocity, volumetric flow rate, pressure gradient, resistance to blood flow and shear stress have been...

In this study, a white light particle image velocimetry (WL PIV) system which employs a light sheet generated with a flash was used. The system was developed in order to provide a cost-efficient and safe alternative to laser systems while keeping the accuracy limits required for hydraulic model tests. To investigate the accuracy of WL PIV method under different flow conditions, experiments were...

Fluid shear stress is an important regulator of vascular and endothelial cell (EC) functions. Its effect is dependent not only on magnitude but also on flow type. Although laminar flow predominates in the vasculature, transitional flow can occur and is thought to play a role in vascular diseases. While a great deal is known about the mechanisms and signaling cascades through which laminar shear...

The wall shear stress pattern was measured in a rigid plastic cast of a canine artery during steady flow by means of an electrochemical technique. The topographic distribution of shear stress is very nonuniform, with regions of high and low shear in close proximity. The steady shear stresses are highest at the leading edge of flow dividers and at the entrance regions to branch vessels. The shap...

Laser Doppler Velocimetry (LDV) has been employed to determine pseudo-turbulence characteristics of the flow field around bubble train forming in non-Newtonian caboxymethylcellulose (CMC) aqueous solution at low gas flow rate condition. The Reynolds stress and turbulent intensity of the liquid were investigated by means of Reynolds time-averaged method. The experimental results show that ax...

This paper presents a methodology to determine simultaneously (a) the flow stress at high deformation rates and temperatures that are encountered in the cutting zone, and (b) the friction at the chip–tool interface. This information is necessary to simulate high-speed machining using FEM based programs. A flow stress model based on process dependent parameters such as strain, strain-rate and te...

In the Manning equation the hydraulic radius can be defined as the cross-section dimension of the shape. In pipe flow the bed shear stress is assumed to be uniformly distributed along the wetted perimeter which cannot be true in open channel flow. Hence, three approximation of the true boundary shear-stress distribution are examined and more practical conveyance depth or resistance radius formu...

Hindered barrier function has been implicated in the initiation and progression of atherosclerosis, a disease of focal nature associated with altered hemodynamics. In this study, endothelial permeability to macromolecules and endothelial electrical resistance were investigated in vitro in monolayers exposed to disturbed flow fields that model spatial variations in fluid shear stress found at ar...

It is well-known that laminar flow of a liquid in a duct is predicted to choke if the viscosity of the liquid increases exponentially with increasing pressure. In other words, the pressure drop in the duct is predicted to become unbounded when the volumetric flow rate reaches a critical finite value. Choking is not observed in practice, however: the reason why is investigated here. It is shown ...