background : the main objective of this study was to design, formulate and evaluate the physicochemical properties of 500 mg acetaminophen effervescent tablets, in order to accelerate its analgesic and antipyretic effects in patients with pill swallowing problems. methods : formulations with 500 mg of acetaminophen were prepared with effervescent bases including tartaric acid, citric acid, sodi...

The purpose of this research work was to obtain directly compressible enteric recrystallized agglomerates of erythromycin containing enteric polymers by emulsion solvent diffusion technique. Selected solvent for the process includes the best solvent (ethyl alcohol), non-solvent (distilled water) and bridging liquid (chloroform) according to their solubility in different organic solvent. The dif...

Manufacturers of pharmaceutical solid dosage forms aim for a reduced production time and a shorter "time-to-market." Therefore, continuous manufacturing gains increasing interest in the pharmaceutical industry. For continuous manufacturing, the quality of produced pharmaceuticals should be assessed in real-time (in-line, on-line, and at-line) and not via the traditional off-line, often destruct...

BACKGROUND AND METHODS The aim of this study was to develop an immediate-release pellet formulation with improved drug dissolution and adsorption. Carbamazepine, a poorly water-soluble drug, was adsorbed into mesoporous silica (SBA-15-CBZ) via a wetness impregnation method and then processed by extrusion/spheronization into pellets. Physicochemical characterization of the preparation was carrie...

Ibuprofen solid dispersions were prepared by the solvent and fusion-solvent methods using polyethylene glycol (PEG), polyvinylpyrrolidone (PVP), eudragit RS PO, eudragit RL PO and hydroxypropylmethylcellulose (HPMC) as carriers to improve physicochemical characteristics of ibuprofen. The prepared solid dispersions were evaluated for the flowability, solubility characteristics and dissolution be...

Particle size and shape influence the production of solid dosage forms. This study aimed to use the three shape descriptors available in the literature to describe the shapes of six compounds, and evaluate whether angle of repose might predict the flowability of a powder sample the same as those made by compressibility index and Hausner ratio. Images of cephalexin monohydrate, niacin, nystatin,...

Guaifenesin, a highly water-soluble active (50 mg/mL), classified as a BCS class I drug. Owing to its poor flowability and compressibility, formulating tablets especially high-dose one, may be a challenge. Direct compression may not be feasible. Bilayer tablet technology applied to Mucinex®, endures challenges to deliver a robust formulation. To overcome challenges involved in bilayer-tablet ma...

Abstract: This study investigated the effects of different fiber contents by volume (0%, 1%, 2%, and 3%) on flowability, entrapped air content, and compressive and flexural strength of ultra high performance concrete (UHPC). Four water-to-binder ratios (0.18, 0.20, 0.22, 0.24) were used and four different dosages of superplasticizer were introduced for preparing each water-to-binder ratio mixtu...

In additive manufacturing, powder characteristics play an important role in terms of flowability and densification, which can be improved by the use spherical powders. this study, irregular was spheroidised plasma treatment, properties were measured. Powder characterisation conducted to determine morphology, particle size distribution as well flowability. Spherical AISI 304 stainless steel powd...

To improve the powder properties of active pharmaceutical ingredients (APIs), we coated APIs with silica nanoparticles using a dry process that allowed for direct compression into tablets. The coating performed different apparatuses (a batch-type high-speed shear mixer (Mechanomill) and continuous conical screen mill (Comil)) resulting dry-coated were compared. Ethenzamide (ETZ), which has low ...