Epileptic seizures are commonly characterized as 'hypersynchronous states'. This habit is doubly misleading, because seizures are not necessarily synchronous and are not unchanging 'states' but dynamic processes. Here the temporal evolution of the correlation structure in the course of 100 focal onset seizures of 60 patients recorded by intracranial multichannel EEG was assessed. To this end a ...

OBJECTIVE To explore the causative role of PCDH19 gene (Xq22) in female patients with epilepsy. METHODS We studied a cohort of 117 female patients with febrile seizures (FS) and a wide spectrum of epilepsy phenotypes including focal and generalized forms with either sporadic or familial distribution. RESULTS PCDH19 screening showed point mutations in 13 probands (11%). Mean age at seizure o...

Gelastic seizures (GS) describe ictal laughter and are associated with hypothalamic lesions, as well as other cortical areas. Dacrystic seizures (DS), characterized by ictal crying, also have been reported in hypothalamic lesions and focal epilepsy. We describe a young girl with drug resistant focal dyscognitive seizures associated with gelastic and dacrystic features. However, neither laughter...

Suvasini Sharma, DM* Naveen Sankhyan, DM* Konanki Ramesh, MD Sheffali Gulati, MD Epilepsy of infancy with migrating focal seizures is a rare, infantile epileptic encephalopathy characterized by normal early development, refractory focal seizures arising independently from both hemispheres, and severe psychomotor retardation. In the revised terminology by the International League Against Epileps...

Dyke-Davidoff-Masson Syndrome (DDMS) is a rare syndrome characterized with specific clinical and radiological findings due to involvement of the developing brain cerebral hemiatrophy one hemisphere. The was first described from Dyke, Davidoff Masson in 1933 series nine patients. has two forms, congenital acquired forms etiological factors vary brain. Most common symptom are focal or secondary g...

Seizures are a symptom and not a disease. A seizure is the result of an abnormal electrical discharge of a collection or group of living but damaged or abnormal neurons. When the group of neurons is in the cerebral cortex, a focal or partial seizure occurs , producing abnormal activity related to that part of the brain. The victim may experience a focal jerking or focal numbness, or flashing li...