6-Mercaptopurine and mitomycin C were used in combination drug therapy to produce a prolongation of skin allograft survival.

The present study examines the effect of combinations of gabapentin (Neurontin) and a selective neurokinin (NK)(1) receptor antagonist, 1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-[(1-phenylethyl)amino]ethyl]-2-benzofuranylmethyl ester (CI-1021), in two models of neuropathic pain. Dose responses to both gabapentin and CI-1021 were performed against static allodynia induced in the streptozocin and ...

The activities of ampicillin, ampicillin-sulbactam, amoxicillin, amoxicillin-clavulanic acid, ticarcillin, ticarcillin-clavulanic acid, piperacillin, piperacillin-tazobactam, aztreonam, and aztreonam-clavulanic against Stenotrophomonas maltophilia strains for which the MICs of penicillins and commercially available b-lactam– b-lactamase inhibitor combinations were higher than the breakpoints us...

Previous studies in the lab identified a series of alanine substitutions in the mucin domain-deleted Ebola virus glycoprotein 1 (EBOVΔO GP1) that enhance EBOV GP pseudovirion transduction efficiency by about two fold above wild type glycoprotein (1). To determine if combining these alanine substitutions resulted in even higher transduction levels, a series of mutants were generated and assessed...

We studied the mechanisms and dynamics of the development of resistance to ceftazidime (CAZ) alone or combined with tobramycin (TOB) or ciprofloxacin (CIP) in vitro and in vivo (using a mouse model of lung infection with human antibiotic regimens). Pseudomonas aeruginosa strain PAO1 and its hypermutable derivative PAODeltamutS were used, and the results were compared with those previously obtai...

BACKGROUND Variance in microarray studies has been widely discussed as a critical topic on the identification of differentially expressed genes; however, few studies have addressed the influence of estimating variance. METHODOLOGY/PRINCIPAL FINDINGS To break intra- and inter-individual variance in clinical studies down to three levels--technical, anatomic, and individual--we designed experime...

This paper describes XRCE’s participation in Large Scale Visual Concept Detection and Annotation Task [16] and Photo Retrieval Task [17] of ImageCLEF 2009. Those tasks both use a new collection which is different and which is much larger than the ones used in past sessions. Moreover, new kinds of challenge to tackle were designed such as new categories to detect or new types of topic to deal wi...