Background and Objective: As infertility is rapidly becoming a major medical problems among Sudanese females, that has an impact on ovulation and menstruation and other complications, the aim of our present study to investigate the concentration and evaluate potential role of luteinizing hormone, follicle stimulating hormone and esteradiol in Sudanese infertile females, that may help and facili...

The gonadotropin known as follicle-stimulating hormone (FSH) plays a key role in regulating reproductive processes. Physiologically active FSH is a glycoprotein that can accommodate glycans on up to four asparagine residues, including two sites in the FSHα subunit that are critical for biochemical function, plus two sites in the β subunit, whose differential glycosylation states appear to corre...

Background: Infertility is defined as the inability to conceive after one two years of unprotected intercourse. It types: primary infertility and secondary 5On basis etiopathology divided into five groups: unexplained (28%), male factor (24%), ovarian dysfunction (21%), tubal (14%) others (13%). Luteinizing hormone (LH) follicle-stimulating (FSH) are integral parts neural endocrine interchange ...

Studies of human follitropin (hFSH) structure-activity relationships from the author' s laboratory are reviewed. These include mutagenesis studies that complemented the determination of the three dimensIonal structure of hFSH. Despite a large extracellular domain of the FSH receptor and the complexity and size of both the receptor and the hFSH molecule, only a handful of hFSH amino acids are re...

FD is a genetic non-inherited condition caused by missense mutation in the gene GNAS1 on chromosome 20, that encodes the alpha subunit of the stimulatory G protein-coupled receptor, Gsα. The activating mutations occur post-zygotically, replacing the arginine residue amino acid with either a cystein or a histidine amino acid. The mutation selectively inhibits GTPase activity, resulting in consti...

Copyright © 2016 by author(s) and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/license s/by/4.0/ Abstract Follicle stimulating hormone (FSH) is a kind of glycoprotein gonadotropin, and plays an important role in the diagnosis and treatment of infertility. Follicle stimulating hormon...