Children in the warm rain forest are at risk of having their lung function compromised by a variety of factors, including smoke from wood fires. A total of 358 children from a fishing port and 400 children living in a farm settlement were tested to determine their peak expiratory flow rate (PEFR), forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), forced expiratory volume in 1...

BACKGROUND There are several ways to measure the respiratory system, among them inductance plethysmography and three-dimensional kinematic analysis, methods of high cost and difficult transportability. The objective of this study was to correlate respiratory volumes obtained by spirometry standard equipment with a biomechanical model photogrammetric analysis of adolescents. METHODS We evaluat...

Forced expiratory spirograms were obtained before and for six hours after 25 subjects ingested ephedrine and placebo in a double-blind crossover study. Significant changes in the forced vital capacity (FVC) and the forced expiratory volume in one second (FEV1.0) were noted on days when ephedrine was administrated, while the mean forced expiratory flow during the middle half of the FVC (FEF25-75...

background: postoperative pulmonary dysfunction is one of the most frequent complications after cardiac surgery and it is believed to result from the use of cardiopulmonary bypass (cpb). in this study, we investigated the effect of low tidal volume ventilation during cpb on postoperative gas exchange and lung mechanics. methods: this prospective randomized study included 100 patients undergoing...

Abbreviations: chronic obstructive pulmonary disease, COPD; forced expiratory volume in 1 second, FEV1; patient reported outcomes, PROs; St. George’s Respiratory Questionaire, SGRQ; transition dyspnea index, TDI Citation: Donohue JF. Editorial: Forced expiratory volume in 1 second and patient-reported outcomes: closer than you think. Chronic Obstr Pulm Dis (Miami). 2016; 3(2):512-514. doi: http...

Systemic CRP (C-reactive protein) has been associated with impaired lung function. A causal relationship would increase the value of CRP as both a diagnostic and therapeutic tool. We assessed the association between lung function parameters, circulating CRP and CRP polymorphisms using Mendelian randomization in efforts to attribute causality to known associations. Spirometric parameters of FEV1...

The prevalence of asthma seems to be on the increase and risk factors are not well-established. To investigate the relationship between asymptomatic increased bronchial responsiveness to exercise (BRE) and subsequent development of asthma, we studied a population sample of children and adolescents, aged 7-17 yrs at enrollment, examined twice 6 yrs apart (54 and 68%, respectively, of the origina...

BACKGROUND The efficacy of decision making based on longitudinal spirometric measurements depends critically on the precision of the available data, which is determined by the magnitude of the within-person variation. AIMS Firstly, to describe and investigate two statistical methods-a pairwise estimate of within-person standard deviation s(p) and the reliability coefficient G-for use in the m...

Exhaled nitric oxide (NO) is altered in asthmatic subjects with exercise-induced bronchoconstriction (EIB). However, the physiological interpretation of exhaled NO is limited because of its dependence on exhalation flow and the inability to distinguish completely proximal (large airway) from peripheral (small airway and alveolar) contributions. We estimated flow-independent NO exchange paramete...