Genetic association studies have explained only a small proportion of the estimated heritability of complex traits, leaving the remaining heritability "missing." Genetic interactions have been proposed as an explanation for this, because they lead to overestimates of the heritability and are hard to detect. Whether this explanation is true depends on the proportion of variance attributable to g...

We have used mutations in the newly identified gene myoblast city to investigate the founder cell hypothesis of muscle development in Drosophila melanogaster. In embryos mutant for myoblast city the fusion of myoblasts into multinucleate muscles is virtually abolished. Nevertheless, a subset of the myoblasts develop specific muscle-like characteristics, including gene expression appropriate to ...

This report reexamines experimentally the problem of competitive indeterminacy in mixed-species populations of the flour beetles, Tribolium confusum and T. castaneum. Indeterminacy takes the form of alternative competitive outcomes: in some replicate cultures one species exterminates the other with a probability, say p, whereas in others, the opposing species wins with a complementary probabili...

the dynamism of the verity proposition has led to its being used in various issues and sciences as the founder for the general and constant principles. the principles of jurisprudence, as a science that is the founder for general rules to arrive at legal rulings, utilizes this proposition in many subdivisions of uṣūl (principles) as well as in resolving problems. in fact, if we do not take the ...

Public corporations often appoint external former founders to their boards in hope that they will encourage a (re-)focus on creating future new business. Seeking investigate this common practice, we integrate upper echelons theory with imprinting theory, arguing founding company indeed represents formative experience leave an imprint and subsequent board decision-making. Subsequent experience, ...

Entrepreneurial ventures rely not only on founders, but also on “joiners” – startup employees who are attracted to entrepreneurship but do not want to be founders themselves. Drawing upon both individual and contextual-level perspectives of entrepreneurship, we examine how interests in being a founder or a joiner form prior to the first career transition. We find that individuals with founder a...

Paternal obesity programs metabolic syndrome in offspring. Low-impact exercise in obese  males improves the metabolic health of female offspring, however whether this occurred in male  offspring remained unknown. C57BL/6NHsd (Harlan) mice were fed a control diet (CD; 6% fat, n =  7) or a high-fat diet (HFD; 21% fat, n = 16) for 18 weeks. After 9 weeks, HFD-fed mice either remained  sedentary (H...

BACKGROUND Afrikaners are a unique ethnic group in South Africa (SA) with well-documented ancestral records spanning a period of over 350 years. They are mainly descended from Dutch, German and French settlers to SA in the 17th and 18th centuries. Today several disorders in this population occur at relatively high frequencies as a result of founder effects.Objective. To determine whether a foun...