Background & Aims: The topical anesthetic effects of diphenhydramine combined with ingredients such as aluminum and magnesium hydroxide have been used for many years in modern medicine. Due to the limited durability of anesthetic mouthwashes due to saliva secretion and the spreading use of herbal and natural medicines in pharmacotherapy, this study was designed to formulate diphenhydramine in t...

GHK is a promising cosmeceutical peptide that stimulates the synthesis of ECM and modulates activity Matrix Metallo Proteinases (MMPs). However, due to hydrophilic properties GHK, skin permeability challenge. To overcome this limitation, we considered two modifications, namely palmitoyl attachment arginine oligomer conjugation. First, evaluated optimal modification for penetration using Franz d...

Objective: The main objective of the current research work was to formulate and evaluate Bosewellia serrata extract loaded transferosomal topical gels. To overcome drawbacks associated with oral administration in Osteoarthritis treatment. Methodology: Transferosomes were developed using different ratios Phospholipon® 90G as phospholipid, Span-60 surfactant cholesterol fluidity buffer. selected ...

The sample preparation of samples containing bovine serum albumin (BSA), e.g., as used in transdermal Franz diffusion cell (FDC) solutions, was evaluated using an analytical quality-by-design (QbD) approach. Traditional precipitation of BSA by adding an equal volume of organic solvent, often successfully used with conventional HPLC-PDA, was found insufficiently robust when novel fused-core HPLC...

Fish-scale collagen peptides (FSCPs) were prepared using a given combination of proteases to hydrolyze tilapia (Oreochromis sp.) scales. FSCPs were determined to stimulate fibroblast cells proliferation and procollagen synthesis in a time- and dose-dependent manner. The transdermal penetration capabilities of the fractionationed FSCPs were evaluated using the Franz-type diffusion cell model. Th...

The objective of this work was to increase the amount of acyclovir in the basal epidermis, site of herpes virus simplex infection, using the solid lipid nanoparticles loaded gel cream as carriers. Solid lipid nanoparticles were prepared by high pressure homogenisation method and incorporated in a semisolid submicron gel cream. Acyclovir distribution into rat skin after topical application of so...

Previous reports show ineffective transdermal delivery of ketorolac by nanostructured lipid carriers (NLCs). The aim of the present work was enhancement of transdermal delivery of ketorolac by another colloidal carriers, lipid nanocapsules (LNCs). LNCs were prepared by emulsification with phase transition method and mixed in a Carbomer 934P gel base with oleic acid or propylene glycol as penetr...

Galantamine hydrobromide is formulated in tablets and capsules prescribed through oral delivery for the treatment of Alzheimer's disease. However, oral delivery of drugs can cause severe side effects such as nausea, vomiting, and gastrointestinal disturbance. Transdermal delivery of galantamine hydrobromide could avoid these unwanted side effects. In this work, galantamine hydrobromide was form...

The objective of the present investigation was to prepare and evaluate ocular inserts of moxifloxacin. An ocular insert was made from an aqueous dispersion of moxifloxacin, sodium alginate, polyvinyl alcohol, and dibutyl phthalate by the film casting method. The ocular insert (5.5 mm diameter) was cross-linked by CaCl2 and was coated with Eudragit S-100, RL-100, RS-100, E-100 or L-100. The in v...