BACKGROUND High blood pressure (BP) poses a major risk for cognitive decline. Aim of the study was to highlight the relationship between cognitive assessment scores and an effective therapeutic BP control. METHODS By medical visit and ambulatory BP monitoring (ABPM), we studied 302 treated hypertensives, subdivided according to office/daytime BP values into 120 with good (GC) and 98 poor (PC)...

Anhedonia is present in Parkinson's Disease (PD) as well as in addictive behaviors. Pathological Gambling (PG) and other Impulse Control Disorders (ICDs) have emerged as iatrogenic complications associated with dopamine replacement therapy. We studied 154 PD patients, divided into three groups: 11 with PG, 23 with other ICDs (compulsive buying, hypersexuality, binge eating), 120 without ICDs. A...

Although gait disorders were described in schizophrenia, motor imagery of gait has not yet been studied in this pathology. We compared gait, motor imagery of gait and the difference between these two conditions in patients with schizophrenia and healthy age-matched controls. The mean ± standard deviation (S.D.) of Timed Up and Go (TUG), imagined TUG (iTUG) and delta time (i.e.; difference betwe...

В этом исследовании рассматривалось влияние выбранного метода анестезии на когнитивные функции в послеоперационном периоде. Анализ когнитивного статуса проведен при помощи нейропсихологического тестирования: шкала лобных дисфункций (Frontal Assessment Battery, FAB), краткая оценки психического (Mini-Mental State Examination, MMSE). Оценивание проводилось три этапа: накануне оперативного вмешате...

Objective To explore the clinical predictors of freezing of gait (FOG) in Chinese patients with Parkinson's disease (PD). Methods This study included 225 patients with PD who completed a three-year follow-up visit. The end-point was the presence of FOG (freezers), which was assessed during the follow-up visit. Group comparisons were conducted, followed by a further forward binary logistic reg...

BACKGROUND In the 24-month MS-STAT phase 2 trial, we showed that high-dose simvastatin significantly reduced the annualised rate of whole brain atrophy in patients with secondary progressive multiple sclerosis (SPMS). We now describe the results of the MS-STAT cognitive substudy, in which we investigated the treatment effect on cognitive, neuropsychiatric, and health-related quality-of-life (HR...

BACKGROUND in a secondary analysis of a randomised controlled trial, we investigated whether 6 months of music-based multitask training had beneficial effects on cognitive functioning and mood in older adults. METHODS 134 community-dwellers aged ≥65 years at increased risk for falling were randomly assigned to either an intervention group (n = 66) who attended once weekly 1-h supervised group...

Background: People with Alzheimer’s disease (AD) who present with prominent frontal features such as a dysexecutive syndrome may be difficult to differentiate clinically from subjects with frontotemporal lobar degeneration (FTLD). This study was performed to improve the differential diagnosis between AD and FTLD and to better characterize the AD subgroup with greater executive dysfunction. Meth...