When estimating long-term glycemic control, A1C is considered the gold standard (1–3), but patients with seemingly equivalent A1C differ in their risk for microvascular complications (4,5). Recently, the “glycation gap,” defined as the difference between the measured A1C and that which would be predicted from another measure of glycemic control, fructosamine, has been proposed as a means of ide...

To explore further the relation between admission glucose concentration and outcome in stroke, we measured glucose, fructosamine, and glycosylated hemoglobin concentrations on admission in 216 patients seen within 24 hours after the onset of their first stroke. Fructosamine concentration reflects the degree of glycemia in the preceding 4-6 weeks and glycosylated hemoglobin concentration reflect...

The protein-based secondary standardsfor serum fructosamine in a commercial test kit (Roche Diagnostics) have recently been modified by the manufacturer. Under certain assay conditions, the new calibrator gave significantly greater serum fructosamine values than those obtained with the originally supplied calibrator. However, for 20-4, samples and absorbance measurements at 10 and 15 mm, hereaf...

OBJECTIVE To compare the associations of diabetes mellitus risk factors with nontraditional markers of hyperglycemia (glycated albumin, fructosamine, 1,5-anhydroglucitol (1,5-AG)) to those observed with traditional markers (fasting glucose, hemoglobin A1c (HbA1c)). DESIGN Cross-sectional study. SETTING The community-based Atherosclerosis Risk in Communities (ARIC) Study cohort. PARTICIPAN...

OBJECTIVE Fructosamine, glycated albumin, and 1,5-anhydroglucitol (1,5-AG) are of interest for monitoring short-term glycemic control in patients with diabetes; however, their associations with diabetes risk are uncharacterized. RESEARCH DESIGN AND METHODS We used Cox proportional hazards models to examine the associations of fructosamine, glycated albumin, and 1,5-AG with incident diabetes i...

There is limited information on the burden of diabetic nephropathy in developing countries. This study aimed to determine the prevalence of and factors associated with nephropathy among diabetic patients attending an outpatient clinic in Harare, Zimbabwe. In an analytical cross-sectional study, diabetic patients were consecutively enrolled and a questionnaire administered, clinical assessment c...

Methodological problems with the assay of fructosamine in serum--standardization, matrix effects, and dependence on buffer pH--have been minimized with a method involving colorimetric assay of each specimen and subsequent re-assay after standard addition of 1-deoxy-1-morpholinofructose. Absorbance at optimum wavelength of 540 nm varies linearly with fructosamine concentration to at least 5.5 mm...

To assess the value of various methods for long-term follow-up of diabetic patients, we compared the concentrations of fructosamine in serum with those of various glycated proteins: hemoglobin (HbA1C), total serum proteins (G-prot), and albumin (G-alb), assayed in 30 pregnant insulin-dependent diabetics every two weeks after initial determination of a 24-h blood glucose profile. HbA1C correlate...