Health is a continuum of an optimized state of a biologic system, an outcome of positive relationships with the self and others. A healthy system follows the principles of systems science derived from observations of nature, highlighting the character of relationships as the key determinant. Relationships evolve from our decisions, which are consequential to the function of our own biologic sys...

Introduction: Deucravacitinib, an oral, selective, allosteric tyrosine kinase 2 inhibitor, is approved by the US FDA for treatment of adults with moderate-to-severe plaque psoriasis who are candidates systemic therapy or phototherapy. Deucravacitinib was significantly more efficacious than placebo apremilast and well tolerated in previous reports from phase 3 POETYK PSO-1 trial. Here, we examin...

In this paper we explore the boundary between biology and the study of formal systems (logic).

Two hundred and thirty-three 5-month-old infants and their mothers participated in a study designed to examine the influence of maternal sensitivity and infant neurophysiology, as well as interactions between these, on infants' regulatory behavior and reactivity to emotional challenge. Maternal sensitivity was measured during two mother-child free-play episodes prior to the challenge task. Infa...

1Department of Health, Campus Teresina Central, Federal Institute of Education, Science and Technology of Piauí, Teresina, PI, Brazil, 2Department of Pharmacy, State University of Paraíba, Campina Grande, PB, Brazil, 3College of Pharmacy, Campus Minister Petronio Portela, Federal University of Piauí, Teresina, PI, Brazil, 4Laboratory of Experimental Neurochemistry Research, Federal University o...

We introduce a strong notion of quasiconvexity in finitely generated groups, which we call stability. Stability agrees with quasiconvexity in hyperbolic groups and is preserved under quasi-isometry for finitely generated groups. We show that the stable subgroups of mapping class groups are precisely the convex cocompact subgroups. This generalizes a well-known result of Behrstock [Beh06] and is...

OBJECTIVE To review the structure, function, clinical utility, and safety of current biologic targeted therapies being used for the treatment of asthma. DATA SOURCES Medical literature obtained from PubMed and OVID searches from June to November 2013. STUDY SELECTIONS Studies were selected based on article impact, relevance, and clinical significance. Particular emphasis was placed on artic...