240 Mold Sensitization in Chronic Rhinosinusitis Patients Radoslaw Gawlik, MD, PhD, and Eugeniusz Czecior, MD, PhD. Internal Medicine, Allergy and Clin Immunology, Silesian University of Medicine, Katowice, Poland; Silesian University of Medicine, Zabrze, Poland. Background: It is estimated that about 10% of the population have IgE antibodies to common inhalant molds. Exposure to fungal allerge...

240 Mold Sensitization in Chronic Rhinosinusitis Patients Radoslaw Gawlik, MD, PhD, and Eugeniusz Czecior, MD, PhD. Internal Medicine, Allergy and Clin Immunology, Silesian University of Medicine, Katowice, Poland; Silesian University of Medicine, Zabrze, Poland. Background: It is estimated that about 10% of the population have IgE antibodies to common inhalant molds. Exposure to fungal allerge...

Introduction and objective: Detection of the common allergen airborne fungi in any region is critical for prevention and treatment of allergic fungal diseases. Therefore, this study was conducted to identify the most common airborne fungal species of Isfahan, investigate their allergic reactions in animal and obtain local fungal strains for use as antigens in allergy tests to be used. Materials...

Abstract Allergic asthma is a chronic inflammatory disease affecting the lungs which mediated by allergen-specific IgE and type 2 cytokines. cytokine production require Tfh13 cell Th2 polarization, respectively, must first be primed dendritic cells (DC). Recent studies demonstrate that cellular metabolic perturbations critically regulate DC activation subsequent T priming. To characterize mecha...

BACKGROUND The relationship between sensitization to allergens and disease is complex. OBJECTIVE We sought to identify patterns of response to a broad range of allergen components and investigate associations with asthma, eczema, and hay fever. METHODS Serum specific IgE levels to 112 allergen components were measured by using a multiplex array (Immuno Solid-phase Allergen Chip) in a popula...

Cladosporium herbarum is an important allergenic fungal species that has been reported to cause allergic diseases in nearly all climatic zones. 5-30% of the allergic population displays IgE antibodies against molds. Sensitization to Cladosporium has often been associated with severe asthma and less frequently with chronic urticaria and atopic eczema. However, no dominant major allergen of this ...

BACKGROUND Severe asthma is a largely heterogeneous disease with varying phenotypic profiles. The relationship between specific allergen sensitization and asthma severity, particularly in Asia, remains unclear. We aim to study the prevalence of specific allergen sensitization patterns and investigate their association with outcomes in a severe asthma cohort in an Asian setting. METHODS We con...

OBJECTIVES To evaluate the sensitization to aeroallergens determined by skin prick test (SPT) in Brazilian adolescents, and to correlate its positivity with the diagnosis of asthma and/or rhinitis based on the written questionnaire (WQ) of ISAAC phase III study. PATIENTS AND METHODS A total of 996 adolescents (387 boys) were selected by systematic samples. A standard allergen extracts panel (...

In patients with respiratory allergy, cross-reactivity between aeroallergens and foods may induce food allergy, symptoms ranging from oral allergy syndrome to severe anaphylaxis. Clinical entities due to IgE sensitization to cross-reactive aeroallergen and food allergen components are described for many sources of plant origin (pollen-food syndromes and associations, such as birch-apple, cypres...

Allergic rhinitis (AR) is especially prevalent among the population of large cities. Immunologically, the airway epithelium is a region where the population of allergen-presenting cells concentrates. These cells actively express a group of receptors of the innate immune system. A specific cytokine profile is its representation. The study was aimed at evaluating the cytokine profile in patients ...