Notoginseng (Panax notoginseng), a valuable herbal medicine, has high death rates in continuous cropping systems. Variation in the soil microbial community is considered the primary cause of notoginseng mortality, although the taxa responsible for crop failure remains unidentified. This study used high-throughput sequencing methods to characterize changes in the microbial community and screen m...

BACKGROUND In contrast to the increasing numbers of agents for the treatment of invasive fungal infections, discoveries of new antifungal agents with therapeutic value in dermatomycoses are reported only rarely. METHODS Abafungin (chemical abstracts service registry No. 129639-79/8) is the first member of a novel class of synthetic antifungal compounds, the arylguanidines. It was first synthe...

Trichothecenes are fungal sesquiterpenoid compounds, the majority of which have phytotoxic activity. They contaminate food and feed stocks, resulting in potential harm to animals and human beings. Trichoderma brevicompactum and T. arundinaceum produce trichodermin and harzianum A (HA), respectively, two trichothecenes that show different bioactive properties. Both compounds have remarkable anti...

schizophrenia is a severe psychiatric illness with a lifetime prevalence of ˜1% that imposes a huge toll on patients, their families and public health services worldwide. delusions, hallucinations, disorganized speech, grossly disorganized or catatonic behavior and negative symptoms constitute the core symptoms of schizophrenia. although the neurotransmitter dopamine plays a prominent role in t...

Background: IGF-1 and certain other cytokines have been shown to exert inflammatory/anti-inflammatory roles in chronic joint diseases. Objective: To assess the effect of IGF-1, IL-27 and IL-35, their interaction and their receptor expression in a rheumatoid arthritis model. Methods: Freund’s adjuvant-induced chronic joint inflammation was operated on 160 male rats. Animals were divided into his...

Occurrence of culturable Fungi and Oomycota in root-soil habitat of potato cv. Owacja in organic and integrated production systems at Osiny (northern Poland) was compared in 2008–2010. The densities of both pathogens were significantly greater in the organic system. The eudominant fungal taxa (with frequency > 10% in at least one habitat) included species of Fusarium + Gibberella + Haematonectr...

In the Bogota Plateau (Bogota Savanna-Colombia), strawberry cultivation (Fragaria × ananassa Duch.) is established from 2,000 to 2,800 m a.s.l. this environment relative humidity generally greater than 70% and temperature fluctuates between 14 22°C; a favorable climate for development of fungal diseases. Gray mold (Botrytis cinerea) most important disease here fruit losses can exceed 40% produc...

The world's population is growing, which requires more resources, including food. Some necessary foods, such as berries, are very perishable fresh products that suffer contamination by pathogens, generating great economic losses. Various physical and chemical strategies have been used to mitigate these losses over the years, use of pesticides. However, negative impact on environment human healt...