Fungal Rhinosinusitis (FRS) is a relatively common, often misdiagnosed disease process of the paranasal sinuses [1-3]. The incidence of the disease is 37 million cases that encompass a wide spectrum of immune and pathological responses, including invasive, chronic granulomatous and allergic conditions. A recent attempt was made to classify the various types of fungal sinusitis [4]. The current ...

More than 1·6 million people are estimated to die of fungal diseases each year, and about a billion people have cutaneous fungal infections. Fungal disease diagnosis requires a high level of clinical suspicion and specialised laboratory testing, in addition to culture, histopathology, and imaging expertise. Physicians with varied specialist training might see patients with fungal disease, yet i...

(1-3)-β-d-Glucan (BDG) from cerebrospinal fluid (CSF) is a promising marker for diagnostic and prognostic aid of central nervous system (CNS) fungal infection, but its relationship to serum values has not been studied. Herein, we detected BDG from CSF at levels 2-fold lower than those in serum in patients without evidence of fungal disease but 25-fold higher than those in in serum in noncryptoc...

Fungal meningitis is a serious disease caused by a fungal infection of the central nervous system (CNS) mostly in individuals with immune system deficiencies. Fungal meningitis is often fatal without proper treatment, and the mortality rate remains unacceptably high even with antifungal drug interventions. Currently, cryptococcal meningitis is the most common fungal meningitis in HIV-1/AIDS, an...

Cystic fibrosis airways are frequently colonised with fungi. However, the interaction of these fungi with immune cells and the clinical relevance in cystic fibrosis lung disease are incompletely understood.We characterised granulocytes in airway fluids and peripheral blood from cystic fibrosis patients with and without fungal colonisation, non-cystic fibrosis disease controls and healthy contro...

The incidence of fungal peritonitis (FP) and the fungi that caused FP were evaluated in 422 patients treated with peritoneal dialysis. During an 11-year period, 804 episodes of peritonitis occurred, 46 (5.7%) of which were caused by fungi. Treatment was successful for 39 patients. Early diagnosis of FP and prompt therapy decreases morbidity and mortality.

In October 2012, the CDC reported an outbreak of fungal meningitis associated with methylprednisolone injections [1]. Although the index case had Aspergillus fumigatus meningitis [2], subsequent reports indicated that the majority of affected patients had meningitis caused by Exserohilum rostratum, an extremely rare cause of human fungal disease [1,3,4]. The outbreak is presumably the result of...

Recent findings provide evidence that fungal structures can be detected in brain tissue from Alzheimer's disease (AD) patients using rabbit polyclonal antibodies raised against whole fungal cells. In the present work, we have developed and tested specific antibodies that recognize the fungal proteins, enolase and β-tubulin, and an antibody that recognizes the fungal polysaccharide chitin. Consi...

Vol. 10 No. 1, January-March 2008 5 Introduction Allergic fungal sinusitis is a benign noninvasive sinus disease, believed to be an allergic reaction to aerosolized environmental fungi. It has been almost three decades when in 1976 Safirstein noted that the combination of polyposis, crust formation and sinus cultures yielding aspergillus was similar to the constellation of findings observed in ...

the dry bubble disease, caused by lecanicillium fungicola, is an important fungal disease of white button mushroom in iranian mushroom production farms. twenty-three isolates of the pathogen collected in iran and identified as l. fungicola var. fungicola, were compared for genetic polymorphism, diversity in growth rate and virulence. ten universal rice primers (urp) were used to evaluate the ge...