The association between primary biliary cirrhosis (PBC) and autoimmune hemolytic anemia (AIHA) is uncommon; only fourteen such case reports have been described. In this report, three patients who developed AIHA on the basis of PBC underwent successful therapy with corticosteroids and ursodeoxycholic acid (UDCA). Patient 3 was more complicated, suffering from PBC, Evans syndrome, Sjögren syndrom...

autoimmune haemolytic anaemia (aiHa) is a rare disease. in clinical practice, diagnosis and treatment of aiHa turns out to be troublesome. Correct diagnosis is dependent on proper comprehension of the pathophysiology and the laboratory tests performed by the transfusion laboratory. the present review provides a short overview on the pathogenesis of autoimmune haemolytic anaemia. the diagnostic ...

Autoimmune hemolytic anemia (AIHA) is rarely seen in Hodgkin lymphoma (HL) patients, with a reported incidence of 0.2–4.2%.1-3 Sporadic case reports and reviews have shown that when AIHA occurs in HL patients, it happens mostly at stages III and IV of nodular sclerosis HL (NSHL) or mixed cellularity HL (MCHL).4 We present a case of AIHA at the time of diagnosis of classic HL, stage IIIB, with a...

Autoimmune hemolytic anemia (AIHA) is a relatively rare disorder with an incidence of 1-3 per 100,000 [1]. Warm AIHA (WAIHA) is typically due to IgG autoantibodies with optimal reactivity at 37°C and account for the vast majority of AIHA cases (80-90%) [1,2]. Clinical presentation can range from an asymptomatic, compensated hemolytic anemia to acute life-threatening hemolysis. Hemolysis is typi...

marrow examination actually showed relative erythroid hypoplasia. Many patients with homozygous thalassemia have intense erythropoietic marrow activity, with M:E ratios of 1:20. Thus, in this case, a M:E ratio of 1:8 may not truly reflect hyperplasia relative to this child’s baseline condition. Due to the different results reported in the immunohematologic studies, a definite explanation about ...

A 58-year-old man with warm-antibody-mediated autoimmune hemolytic anemia (AIHA) refractory to prednisolone, azathioprine, splenectomy, rituximab and combination chemotherapy, and with unacceptably high transfusion requirement, was treated with alemtuzumab. After a cumulative dose of 883 mg of alemtuzumab, the AIHA remitted completely, with normalization of hemoglobin and transfusion-independen...

Varicella is usually benign exanthematous disease, which primarily affects children. The common complications are bacterial infection of skin eruptions, pneumonia, cerebellar ataxia, hepatitis, thrombocytopenia and arthritis [1]. Autoimmune hemolytic anemia (AIHA) is a rare complication of varicella and only few cases are reported [2-5]. Overall the incidence of AIHA in children is as low as 0....

Autoimmune hemolytic anemia (AIHA) is most often idiopathic. However, in recent years, AIHA has been noted with increased incidence in patients receiving purine nucleoside analogues for hematologic malignancies; it has also been described as a complication of blood transfusion in patients who have also had alloimmunization. As the technology of hematopoietic stem cell transplantation has become...

Received/Geliş tarihi : December 15, 2012 Accepted/Kabul tarihi : April 30, 2013 To the Editor, The hepatitis virus may play an important role in autoimmune hemolytic anemia (AIHA). We herein report the case of a patient presented to our hospital with hepatitis B virus (HBV) and hepatitis C virus (HCV) coinfection who developed warm-type AIHA. The anemia improved, followed by declined viral lev...

AIHAs can be subdivided according to underlying disease (Table 1). No underlying disease or agent can be distinguished in primary AIHA, whereas in the secondary cases, an associated condition is well documented such as autoimmune diseases, malignancies, infections or drugs. Malignancies are one of the most common causes. AIHA can be seen at the diagnosis or during the course of cancers such as ...