NF-κB and its associated pathways are complicatedly concerned about hepatic homeostasis. Discriminating inhibition of NF-κB signaling has been expected to treat various liver diseases including fulminant hepatitis. To clarify the potential use of thioalkylated mannose-appended dendrimer (generation 3; G3) conjugates with α-cyclodextrin with average degree of substitution of mannose (DSM4) (Man-...

The effect of DPP grains, isolated flavonoids were carried out on the levels steroid hormone and Lipid profile in sera adult female rabbits.
 This animals divided into seven groups, which include. acontrol group, G1,G2,G3:groups orally treated with (12,24,36)mg/kg/day grain while groupsG4,G5,G6:orally (5,10,15) mg/kg/day DDP.
 -Testosterone significantaly increased G3,G4,G6 as compare...

Overexpression of EGFR and versican has been reported in association with breast cancers. Considered oncogenic, these molecules may be attractive therapeutic targets. Possessing anti-apoptotic and drug resistant properties, overexpression of these molecules is accompanied by selective sensitization to the process of apoptosis. In this study, we exogenously expressed a versican G3 construct in b...

BACKGROUND Anal carcinoma is a rare cancer. Surgical treatment is applied for small superficial tumors of the anal margin, the more advanced disease is treated with concomitant chemoradiotherapy. The aim of our study was to evaluate treatment outcomes in patients treated at the Masaryk Memorial Cancer Institute in 2006- 2010. PATIENTS AND METHODS We reviewed the clinical data of 29 newly diag...

Let tsp(G) denote the length of a shortest travelling salesman tour in a graph G. We prove that for any ε > 0, there exists a simple 2-connected planar cubic graph G1 such that tsp(G1) ≥ (1.25 − ε) · |V (G1)|, a simple 2-connected bipartite cubic graph G2 such that tsp(G2) ≥ (1.2 − ε) · |V (G2)|, and a simple 3-connected cubic graph G3 such that tsp(G3) ≥ (1.125− ε) · |V (G3)|.

Aggrecan is the major proteoglycan of the extracellular matrix in cartilage. It contains two N-terminal globular regions, G1 and G2, and one C-terminal globular region, G3. G3 is implicated in the intracellular processing of aggrecan and contains a C-type lectin carbohydrate recognition domain (CRD), frequent occurrences of a C-terminal short complement repeat (SCR) domain, and occasionally an ...

Neuroendocrine neoplasms (NENs) are rare, heterogeneous and ubiquitous tumors commonly localized in the gastrointestinal tract, lung, and pancreas. The clinical behavior of NEN is highly unpredictable; in fact, low-grade cases can unexpectedly be associated with metastases. Currently, the 2010 WHO NEN classification employs histological differentiation and the proliferation index for grading tu...

In the present paper, we study rotational surfaces in the three dimensional pseudo-Galilean space G3. Also, we classify linear Weingarten rotational surfaces in G3. A linear Weingarten surface is the surface having a linear equation between the Gaussian curvature and the mean curvature of a surface. In last section, we construct isotropic rotational surfaces in G3 with prescribed mean curvature...

The t-PA/PAI-1 complex is a good indicator of the release of fibrinolysis activators and inhibitors from the vascular wall, but its clinical significance in chronic ischemic heart disease is unclear. The plasma levels of tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1), and the t-PA/PAI-1 complex (including various coagulation factors) were assayed in 72 patie...

INTRODUCTION Somatostatin receptors (SSTR) are widely distributed in well-differentiated neuroendocrine neoplasms (NEN) and serve as primary targets for diagnostics and treatment. An overexpression of the chemokine receptor CXCR4, in contrast, is considered to be present mainly in highly proliferative and advanced tumors. Comparative data are still lacking, however, for neuroendocrine carcinoma...