نتایج جستجو برای: gabaergic neuron

تعداد نتایج: 73309  

2012
Nicolas Mallet Benjamin R. Micklem Pablo Henny Matthew T. Brown Claire Williams J. Paul Bolam Kouichi C. Nakamura Peter J. Magill

Different striatal projection neurons are the origin of a dual organization essential for basal ganglia function. We have defined an analogous division of labor in the external globus pallidus (GPe) of Parkinsonian rats, showing that the distinct temporal activities of two populations of GPe neuron in vivo are underpinned by distinct molecular profiles and axonal connectivities. A first populat...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1993
S Ferré W T O'Connor K Fuxe U Ungerstedt

Recent pharmacological data suggest that a receptor-receptor interaction between adenosine A2 and dopamine D2 receptors in the brain underlies the behavioral effects of adenosine agonists and adenosine antagonists, such as caffeine and theophylline. According to this interaction, stimulation of A2 receptors inhibits and their blockade potentiates the effects of D2 receptor stimulation. Furtherm...

Journal: :Journal of neurophysiology 2005
Kenji Morita Kunichika Tsumoto Kazuyuki Aihara

Recent in vitro experiments revealed that the GABAA reversal potential is about 10 mV higher than the resting potential in mature mammalian neocortical pyramidal cells; thus GABAergic inputs could have facilitatory, rather than inhibitory, effects on action potential generation under certain conditions. However, how the relationship between excitatory input conductances and the output firing ra...

2012
Javier DeFelipe Pedro L. López-Cruz Ruth Benavides-Piccione Concha Bielza Pedro Larrañaga Stewart Anderson Andreas Burkhalter Bruno Cauli Alfonso Fairén Dirk Feldmeyer Gord Fishell David Fitzpatrick Tamás F. Freund Guillermo González-Burgos Shaul Hestrin Sean Hill Patrick R. Hof Josh Huang Edward G. Jones Yasuo Kawaguchi Zoltán Kisvárday Yoshiyuki Kubota David A. Lewis Oscar Marín Henry Markram Chris J. McBain Hanno S. Meyer Hannah Monyer Sacha B. Nelson

Systematic classification and accepted nomenclature of neuron types are still lacking and much needed. This article describes a possible taxonomical solution, focusing on GABAergic interneurons of the cerebral cortex. We developed a novel, web-based interactive system allowing experts to classify neurons with pre-determined criteria. Using Bayesian analysis and clustering algorithms on the resu...

2005
Kenji Morita Kunichika Tsumoto Kazuyuki Aihara

Recent in vitro experiments revealed that the GABA A reversal potential is about 10 mV higher than the resting potential in mature mammalian neocortical pyramidal cells, thus GABAergic inputs could have facilitatory, rather than inhibitory, effects on action potential generation under certain conditions. However, how the relationship between excitatory input conductances and the output firing r...

GABAergic drugs can change analgesic effect of morphine. Wide dynamic range (WDR) neurons play an important role in pain transmission and may change behaviors in morphine tolerance. In this study WDR neuron behaviors in morphine tolerant rats and rats treated with GABA agonists, were recorded to elucidate the effect of morphine and GABA agonists on WDR behavioral changes. Rats were divided to 4...

GABAergic drugs can change analgesic effect of morphine. Wide dynamic range (WDR) neurons play an important role in pain transmission and may change behaviors in morphine tolerance. In this study WDR neuron behaviors in morphine tolerant rats and rats treated with GABA agonists, were recorded to elucidate the effect of morphine and GABA agonists on WDR behavioral changes. Rats were divided to 4...

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