Recent studies of the chemical structure of glycolipids (Klenk and Gielen, 1961, 1963; Svennerholm and Raal, 1961; Kuhn, 1961; Wolfe and Lowden, 1964) have contributed to our knowledge of the metabolism of different glycolipids. Thus, a low concentration of 3-glucosidase in human brain and other organs will give rise to a blocked degradation of gangliosides, with accumulation of glucocerebrosid...

BACKGROUND Bacterial contamination of colostrum is common and can decrease IgG absorption in neonatal calves. Strategies that mitigate this situation without complicating colostrum management will benefit dairy calf health and survival. OBJECTIVES To evaluate the effects of supplementing colostrum with oligosaccharides (OS) on serum IgG concentration and apparent efficiency of absorption of I...

Recent studies of the chemical structure of glycolipids (Klenk and Gielen, 1961, 1963; Svennerholm and Raal, 1961; Kuhn, 1961; Wolfe and Lowden, 1964) have contributed to our knowledge of the metabolism of different glycolipids. Thus, a low concentration of 3-glucosidase in human brain and other organs will give rise to a blocked degradation of gangliosides, with accumulation of glucocerebrosid...

Recent studies of the chemical structure of glycolipids (Klenk and Gielen, 1961, 1963; Svennerholm and Raal, 1961; Kuhn, 1961; Wolfe and Lowden, 1964) have contributed to our knowledge of the metabolism of different glycolipids. Thus, a low concentration of 3-glucosidase in human brain and other organs will give rise to a blocked degradation of gangliosides, with accumulation of glucocerebrosid...

BACKGROUND Prenatal consumption of oligosaccharides are associated with changes in the maternal gastrointestinal tract (GIT) microbiota with health consequences for the offspring. It has previously been demonstrated that caprine milk oligosaccharides (CMO) stimulate the growth and fermentation rate of Bifidobacterium bifidum AGR2166. OBJECTIVE The objective of this study was to examine the ef...

High-fat (HF) diet and obesity are risk factors for a number of mental health problems including depression, cognitive dysfunction, dementia, and neurodegenerative diseases. Histamine H1 receptors (H1Rs) are involved in many of these conditions. This study examined H1R receptor binding density in the brain of male rats fed a high-saturated fat (HF) diet, as well as the effect of docosahexaenoic...

The sialic acid-like sugar 5,7-diacetamido-3,5,7,9-tetradeoxy-D-glycero-D-galacto-nonulosonic acid, or legion-aminic acid, is found as a virulence-associated cell-surface glycoconjugate in the Gram-negative bacteria Legionella pneumophila and Campylobacter coli. L. pneumophila serogroup 1 strains, causative agents of Legionnaire's disease, contain an alpha2,4-linked homopolymer of legionaminic ...

Introduction of an epoxide function at the C4 position of the glucose moiety of a truncated glucosylceramide (GlcCer) yields two stereoisomeric products namely a gluco- and a galacto-derivative. The effects of both analogues on the [14C]serine incorporation into glycosphingolipids as well as on lactosylceramide (LacCer) synthase activity of primary cultured neurons derived from the telencephalo...