The opsonic properties of immune gammaG-globulins isolated from patients with chronic septicemic conditions, principally subacute bacterial endocarditis were studied. Opsonic capacity as well as complement-fixing properties of gamma-globulins appeared to be closely associated with integrity of Fc structures. Progressive pepsin digestion of immune gammaG-globulins, as monitored by successive los...

T HE PURPOSE of this paper is to report the occurrence of “myeloma gamma globulin” in serum and hydrolytic fragments of gamma globulin in urine of a patient with monocytic leukemia. The case differs in certain respects from the other example of this association reported by Osserman and LawlorY The isolation and characterization of the aberrant proteins and detailed morphologic findings are pres...

T HE PURPOSE of this paper is to report the occurrence of “myeloma gamma globulin” in serum and hydrolytic fragments of gamma globulin in urine of a patient with monocytic leukemia. The case differs in certain respects from the other example of this association reported by Osserman and LawlorY The isolation and characterization of the aberrant proteins and detailed morphologic findings are pres...

There were no significant differences in the pharmacokinetics of micafungin and expression of hepatic multidrug resistance-associated protein 2 (ABCC2/Mrp2) between analbuminemic and Sprague-Dawley rats. Micafungin bound strongly to high-density lipoprotein (HDL) and moderately to gamma globulin. These results suggest that HDL and gamma globulin contribute to the pharmacokinetics of micafungin.

Rats with nephrotoxic serum nephritis may show fixation of complement (C') in the glomeruli during two periods. The first period occurs immediately after the injection of the antisera and extends until the host response occurs. The second period is related to the deposit of rat gamma globulin in the glomeruli presumably occurring at the time of the immune response to the heterologous nephrotoxi...

The L polypeptide chains of certain Bence-Jones proteins of group I have been found in three forms: monomers of molecular weight of about 20,000, dimers which monomerize in dissociating solvents, and dimers which are stable in such solvents. The L polypeptide chains of some Bence-Jones proteins of group II were found to occur naturally only as stable dimers. The L chains of normal human gamma-g...

The genetic factors Gm(a), Gm(b), Gm(x), and Inv(a), Inv(b) described for normal human gamma-globulin were all found in different myeloma proteins. A single myeloma protein never contained more than one product of alternate alleles even in heterozygous individuals. However, factors determined by the two different loci were often found in the same myeloma protein. The Gm(a) character of the myel...

The ability of sera from patients with rheumatoid arthritis to potentiate the agglutination of sensitized particulate bodies has been recognized since Cecil, Nicholls, and Stainsby (1931) noted the agglutination of certain strains of streptococci by these sera. More recently this property has been employed as the basis of a number of clinical tests for the diagnosis of rheumatoid arthritis. The...