Ganoderic Acid (GA), a major bioactive compound isolated from the East Asian medicinal mushroom Ganoderma tsugae, is traditionally believed to have significant properties. GA poorly soluble in water, which poses several challenges terms of its formulation. In this study, tsugae extracts obtained through ethanol extraction were encapsulated nanodispersions via ultrasonic cavitation and solvent e...

Background Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's (AD). The exact mechanism behind PD still unknown and marked by symptoms like bradikynesia, tremors, walking or gait difficulties, etc. current medication used for levodopa, researchers are trying to develop a promising drug PD. In our study, we took Ganodema lucidium mushroom, known as “R...

The traditional Chinese medicinal mushroom, Ganoderma lucidum, has been used in Asia for several thousand years for the prevention and treatment of a variety of diseases, including cancer. In previous work, we purified ganoderic acid T (GA-T) from G. lucidum [28]. In the present study, we investigate the functions of GA-T in terms of its effects on invasion in vitro and metastasis in vivo. A tr...

Ganoderma lucidum is a well-known traditional Chinese medicinal herb containing many bioactive compounds. Ganoderic acid T (GA-T), which is a lanostane triterpenoid purified from methanol extract of G. lucidum mycelia, was found to exert cytotoxicity on various human carcinoma cell lines in a dose-dependent manner, while it was less toxic to normal human cell lines. Animal experiments in vivo a...

Ganoderic acid D (GD) is the major active triterpenoid in Ganoderma lucidum, a medicinal fungus used daily. However, the metabolic fate of GD remains unknown. To know whether GD is extensively metabolized, we first investigated the metabolism of GD in vitro and in vivo. The metabolic profiles of the bile samples obtained from rats in vivo were almost the same as those obtained in vitro. Using u...