In this research, the impact of shoulder width and geometry of gas channel with different structures on proton exchange membrane (PEM) has been investigated using numerical method. 3D, non-isothermal was used with single straight channel geometrywhile maintaining the same boundary conditions and reaction area with addition of humidification for anode and cathode. Our study showed that an ellipt...

introduction: intracellular ph (phi) regulates essentially all aspects of cellular activities. however, it is unknown how endoplasmic reticulum (er) potassium channels sense phi. in this study, we investigate the direct effects of phi on er potassium channels. methods: we used channel incorporation into the bilayer lipid membrane method. l-α-phosphatidylcholine, a membrane lipid, was extracted ...

the world is facing severe challenges in meeting the rapidly growing demand for water resources. in addition,irrigation water which is the largest use of water in most developing countries and arid and semi arid regions, will likelyhave to be diverted increasingly to meet the needs of the households in urban areas and industry sectors whilst remaining aprime engine of agricultural growth. a lin...

atp-sensitive potassium (katp) channel openers have a relaxation effect due to the lower cellular membrane potential and inhibit calcium influx. there has been considerable interest in exploring katp channel openers in the treatment of various diseases such as cardiovascular, cerebrovascular, and urinary system disease and premature labor. the purpose of this study was to synthesize 3,3,6,6-tet...

Zinc is a substance that regulates neural excitability by binding whit sodium channel and potassium channel. The efficiency of free zinc ion, make down the neural survival rate, reduced the peak amplitude of Na+ and make depolarization Na channel, increased the peak amplitude of transition outward k+ currents and delayed rectifier. Also it is an effective blocker of one subtype of tetrodoxine (...

this paper examines the short- and long-run effects of domestic research and development (r&d;) and foreign r&d; (throw the channels of capital goods import and foreign direct investment) on iranian economic growth using of endogenous growth models and bounds test approach to level relationship over the period of 1351-1386. bounds test approach results confirm the existence of long-run relation...

shape error due to elastic recovery of formed part in unloading known as springback, is one of the most important problems of tool design in sheet metal forming processes. many researches have been performed for proposing an efficient method to decrease or compensate springback error in sheet forming processes. these methods are usually based on iterative finite element algorithms. in this pape...

mebudipine is a new dihydropyridine calcium channel blocker, synthesized in our laboratory, for treatment of hypertension. it has shown a better efficacy than other drugs in this group. for assessing the risks of this drug, certain safety tests in the preclinical stage have been performed. in this study mutagenic effect of mebudipine was evaluated using ames assay that could assess the mutageni...

objective(s): thyroid hormones play an essential role in fetal growth and maternal hypo-thyroidism which leads to cardiovascular deficiency in their offspring.  considering this, we intended to investigate the impact of gestational hypothyroidism on offspring vascular contractibility and possible underlying mechanisms. materials and methods: hypothyroidism was induced in female rats by administ...