AIM To evaluate intraocular biodistribution of fluorescent nanoparticles composed of dexamethasone bound to chitosan after intravitreal administration in rabbit eyes. MATERIAL AND METHODS The chitosan and gelatin based nanoparticles were synthetized using a reverse emulsion-double crosslinking technique (ionic and covalent) and then dexamethasone was bound. Two units of 1% suspension of these...

A catalysis-based, label-free, and high-throughput colorimetric protocol has been initially proposed for detecting mercury(II) in blood and wastewater with 96-cell plates, based on the mercury-enhanced catalytic activity of small silver nanoparticles synthesized in a gelatin matrix with unique temperature switchable sol-gel transition.

Gelatin-eudragit L100 nanoparticles of wet size range 170-563nm were prepared by two step dissolvation method and the effect of different concentrations of eudragit L100 and emulsifying agent sodium lauryl sulphate (SLS) on the particle size were studied. Synthesized nanoparticles were characterized by attenuated total reflectance-fourier transform infrared spectroscopy (ATRFTIR) and the mean s...

Pancreatic cancer is a leading cause of cancerdeath, mostly owing to lack of efficient therapeutic options. Upwards of 90% pancreatic tumors over express epidermal growth factor receptor (EGFR) and this largely influences the disease aggressiveness and poor clinical outcome in patients. Non-viral gene therapy has achieved increased attention over the last two decades. In this study type B gelat...

Implant-associated infections still pose a serious threat leading to several complications. This study reported an environmentally benign Ag-containing nanocomposite coating with efficient antibacterial property fabricated on the metal implant via electrophoretic deposition (EPD). In such coatings, Ag2O/AgCl mixed with chitosan/gelatin (CS/G) polymers work together to exert the antibacterial pr...

This work is aimed at preparation of small silver nanoparticles (Ag NPs) with various sizes using two-step preparation method. The silver bromide nanoparticles were prepared in the first step and they were reduced to metal silver nanoparticles in the second step. Size of prepared silver nanoparticles was controlled by using of several modifiers. Two surfactants (SDS and Tween 80) and two natura...

Nanotechnology plays an important role in advanced biology and medicine research particularly in the development of potential site-specific delivery systems with lower drug toxicity and greater efficiency. These include microcapsules, liposomes, polymeric microspheres, microemulsions, polymer micelles, hydrogels, solid nanoparticles etc. In the present study, preparation and characterization of...

Employing environmentally friendly reducing and capping materials to synthesize gold nanoparticles is an exciting research point. However, the used usually need a long reduction time that can take days. In this work, instantaneous production of small-sized (less than 20 nm) investigated using ascorbic acid, gelatin, mixture two agents at different preparation conditions (at room temperature; ± ...

One of the promising fields research is tissue engineering that can facilitate available therapeutic methods. Nanosized hydroxyapatite (HA) one key elements in mineral bone. It possible to affect surrounding osteoprogenitor cells using nano-sized HA and through this improve bone repair changing paracrine signaling. The present paper an attempt prepare evaluate physicochemical properties hydroxy...