Eight F2 populations of crosses carried out between the resistant cultivar Amigo and 8 susceptible bread wheat cultivars were evaluated to study inheritance resistance powdery mildew (Pm) caused byBlumeria. graminis f.sp . tritici also estimate number action genes related adult plant resistance. The response disease was studied in a conditioned glasshouse natural infection open field. Individua...

We investigated the feasibility of transferring naked plasmid DNA containing a therapeutic gene (IL-12) into mice harboring growing Renca tumors. We found that naked DNA transferred into growing Renca and B16(F10) tumors gives higher expression level of reporter gene than complexes of DNA with DDAB/DOPE or DC-Chol/DOPE. Transfer of naked DNA carrying the IL-12 gene into growing Renca tumors cau...

Prosthetics soft tissue trauma is attacked with a combination of theoretical and experimental tools . A novel socket design results, accentuating flesh stress relief at the socket brim . Currently, the novel socket has been fitted to two subjects with long histories of stump trauma ; field test results are not yet available.

Src kinase, a prototype member of the Src family of kinases (SFKs), is over-expressed in various human tumors, and has become a target for anticancer drug design. In this perspective, a series of eighteen 2-pyridone derivatives were synthesized and evaluated for their c-Src kinase inhibitory activity. Among them, eight compounds exhibited c-Src kinase inhibitory activity with IC50 value of less...

The activation of the AGC (protein kinase A/protein kinase G/protein kinase C)-family kinase SGK1 (serum- and glucocorticoid-induced kinase 1) by insulin via PI3K (phosphoinositide 3-kinase) signalling has been appreciated for almost 10 years. PDK1 (phosphoinositide-dependent protein kinase 1), a kinase that phosphorylates the SGK1 catalytic domain at Thr(256), is known to play a critical role ...