Selecting cattle most resistant to the development of infectious diseases will decrease costs of production and should therefore be included in the overall breeding objective. Such selection goals may include resistance to infection with a pathogen (absence of susceptibility), resistance to disease (no-development of disease), tolerance (capability of untreated individuals to maintain a reasona...

The use of animal models in modeling of human genetic disease has many advantages. In some cases, however, this method may not be applicable due to some limitations, such as differences in tissue composition, anatomy and physiology of humans and animals. Isogenic human disease models are a population of cells that are selected or engineered to model a specific genetic disease, in vitro. They ar...

context the pnpla3 i148m variant has been recognized as a genetic determinant of liver fat content and a genetic risk factor of liver damage progression associated with steatohepatitis. the i148m variant is associated with many chronic liver diseases. however, its potential association with inflammatory and autoimmune liver diseases has not been established. evidence acquisition we systemically...