Linkage analysis using maximum-likelihood estimation is a powerful tool for locating genes. As available data sets have grown, the computation required for analysis has grown exponentially and become a significant impediment. Others have previously shown that parallel computation is applicable to linkage analysis and can yield order-of-magnitude improvements in speed. In this paper, we demonstr...

There are two primary objectives of this dissertation. The first goal is to identify certain limits of genetic algorithms that use only fitness for learning genetic linkage. Both an explanatory theory and experimental results to support the theory are provided. The other goal is to propose a better design of the linkage learning genetic algorithm. After understanding the cause of the performanc...

objective: type 2 diabetes (t2d) as a complex disease is the result of genetically heterogeneous factors and environmental issues interaction. linkage and small-scale candidate gene studies were successful in identification of genetic susceptibilities of monogenic form of diseases. however, they were largely unsuccessful while applying to the more common forms of disease. by designing genome wi...

The rate of genetic recombination varies among species, and across different regions of the genome within a species. In the extreme case, all genes in an asexual or selffertilizing species are effectively completely linked, in contrast to the substantial opportunities for recombination in outbreeding sexual species. Several key observations on the relation between patterns of evolution and leve...

Statistical models for genetic linkage analysis of k locus diseases are k-dimensional subvarieties of a (3 − 1)-dimensional probability simplex. We determine the algebraic invariants of these models with general characteristics for k = 1, in particular we recover, and generalize, the Hardy-Weinberg curve. For k = 2, the algebraic invariants are presented as determinants of 32 × 32-matrices of l...

The prevalence of recombination in eukaryotes poses one of the most puzzling questions in biology. The most compelling general explanation is that recombination facilitates selection by breaking down the negative associations generated by random drift (i.e. Hill-Robertson interference, HRI). I classify the effects of HRI owing to: deleterious mutation, balancing selection and selective sweeps o...

Two approaches were used to correlate the Aedes aegypti genetic linkage map to the physical map. STS markers were developed for previously mapped RFLP-based genetic markers so that large genomic clones from cosmid libraries could be found and placed to the metaphase chromosome physical maps using standard FISH methods. Eight cosmids were identified that contained eight RFLP marker sequences, an...