نتایج جستجو برای: genetic short stature

تعداد نتایج: 1022810  

Journal: :Kathmandu University medical journal 2009
U Shrestha S Bhattacharya N K Bhatta C B Jha

OBJECTIVES To analyze chromosomes in children with suspected genetic disorder and to categorize the chromosomal basis of genetic disorder. MATERIALS AND METHODS Thirty children were selected from the patients attending genetic clinic, Department of Pediatrics, B.P. Koirala Institute of Health Sciences presenting with dysmorphic feature, mental retardation, short stature, congenital malformati...

Journal: :Hormone research 2006
M J E Walenkamp J M Wit

In the last few years, our knowledge of genetically determined causes of short stature has greatly increased by reports of challenging patients, who offered the opportunity to study genes that play a role in growth. Since the first paper that showed the etiology of Laron syndrome [Godowski PJ, et al: Proc Natl Acad Sci USA 1989;86:8083-8087], many mutations in the growth hormone (GH) receptor h...

2015
Sonu Acharya Mamta Mohanty Sheetal Acharya

Hallermann-Streiff syndrome (HSS) is a rare genetic disorder that is primarily characterized by distinctive malformations of the skull and facial region, sparse hair, eye abnormalities, dental defects, atrophic skin changes and a proportionate short stature. Here we discuss a case of 9 years-old female child who presented with abnormal facial features, dental problems and associated cardiac pro...

Journal: :Indian Journal of Endocrinology and Metabolism 2012

Journal: :Endocrinology and Metabolism Clinics of North America 2017

Journal: :Archives of Disease in Childhood 1977

Journal: :Pediatric endocrinology reviews : PER 2014
M Hermanussen T Meitinger J D Veldhuis M J Low R Pfäffle K Staub R Panczak D Groth M Brabec M von Salisch C P A Loh V Tassenaar C Scheffler R Mumm E Godina A Lehmann J Tutkuviene S Gervickaite A F M Nierop A Holmgren C Assmann S van Buuren S Koziel E Zadzińska I Varela-Silva J Vignerová E Salama M El-Shabrawi A Huiji T Satake B Bogin

The association between poverty, malnutrition, illness and poor socioeconomic conditions on the one side, and poor growth and short adult stature on the other side, is well recognized. Yet, the simple assumption by implication that poor growth and short stature result from poor living conditions, should be questioned. Recent evidence on the impact of the social network on adolescent growth and ...

Journal: :Hormones 2006
Sofia K Leka Sofia Kitsiou-Tzeli Ariadni Kalpini-Mavrou Emmanuel Kanavakis

Since its discovery in 1997, knowledge about the SHOX gene ( Short stature HOmeoboX-containing gene) has rapidly advanced. Although originally described as causing idiopathic short stature, SHOX mutations are also responsible for growth retardation in Léri-Weill dyschondrosteosis, Langer mesomelic dysplasia and Turner syndrome. Furthermore, SHOX has a broad functional scope and leads to a varie...

Journal: :American journal of human genetics 2011
Andrew Dauber Yongguo Yu Michael C Turchin Charleston W Chiang Yan A Meng Ellen W Demerath Sanjay R Patel Stephen S Rich Jerome I Rotter Pamela J Schreiner James G Wilson Yiping Shen Bai-Lin Wu Joel N Hirschhorn

Height is a model polygenic trait that is highly heritable. Genome-wide association studies have identified hundreds of single-nucleotide polymorphisms associated with stature, but the role of structural variation in determining height is largely unknown. We performed a genome-wide association study of copy-number variation and stature in a clinical cohort of children who had undergone comparat...

Akram Mansouri, Ali Soleymani, Ehsan Shabani, Gholamreza Badfar, Marzieh Parizad Nasirkandy, Masoumeh Shohani, Milad Azami, Shoboo Rahmati,

Growth disorders are considered as one of the common complications of thalassemia major patients. The present study was conducted to examine the prevalence of short stature, underweight, and delayed puberty in patients with thalassemia major in Iran. This review study was conducted based on systematic review and meta-analysis protocol (PRISMA) until 2017. To access relevant literature, two res...

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