نتایج جستجو برای: genome wide association study
تعداد نتایج: 4629884 فیلتر نتایج به سال:
Jonathan M Kocarnik1, S Lani Park2, Jiali Han3,4, Logan Dumitrescu5,6, Iona Cheng7, Lynne R Wilkens2, Fredrick R Schumacher8, Laurence Kolonel2, Chris S Carlson1, Dana C Crawford5,6, Robert J Goodloe5, Holli Dilks5, Paxton Baker5, Danielle Richardson5, José Luis Ambite9, Fengju Song3,10, Abrar A Quresh11, Mingfeng Zhang11, David Duggan12, Carolyn Hutter13, Lucia A Hindorff14, William S Bush5,15...
Genome-wide association studies have been able to identify disease associations with many common variants; however most of the estimated genetic contribution explained by these variants appears to be very modest. Rare variants are thought to have larger effect sizes compared to common SNPs but effects of rare variants cannot be tested in the GWAS setting. Here we propose a novel method to test ...
In 1998, the Qingdao Twin Registry was initiated as the main part of the Chinese National Twin Registry. By 2005, a total of 10,655 twin pairs had been recruited. Since then new twin cohorts have been sampled, with one longitudinal cohort of adolescent twins selected to explore determinants of metabolic disorders and health behaviors during puberty and young adulthood. Adult twins have been sam...
Genome-wide association (GWA) studies have proved extremely successful in identifying novel genetic loci contributing effects to complex human diseases. In doing so, they have highlighted the fact that many potential loci of modest effect remain undetected, partly due to the need for samples consisting of many thousands of individuals. Large-scale international initiatives, such as the Wellcome...
In family-based longitudinal genetic studies, investigators collect repeated measurements on a trait that changes with time along with genetic markers. Since repeated measurements are nested within subjects and subjects are nested within families, both the subject-level and measurement-level correlations must be taken into account in the statistical analysis to achieve more accurate estimation....
We propose a nonparametric association analysis combining both family and unrelated case-control genotype data. Under the assumption of Hardy-Weinberg equilibrium, we formed an affected group to compare with a group of unaffecteds.Comparison with traditional case-control chi-square test and transmission-disequilibrium test shows that this new approach has noticeably improved power. All analysis...
The Framingham Heart Study is a well known longitudinal cohort study. In recent years, the community-based Framingham Heart Study has embarked on genome-wide association studies. In this paper, we present a Framingham Heart Study genome-wide analysis for fasting triglycerides trait in the Genetic Analysis Workshop16 Problem 2 using multivariate adaptive splines for the analysis of longitudinal ...
Many of the hits identified through genome-wide association studies are located outside protein-coding regions, making it difficult to define mechanism. In Nature, Farh et al., (2014) describe an approach to identify causal variants in autoimmune disease as first step to assigning function.
In the post-GWAS (Genome-Wide Association Scan) era, the interpretation of GWAS results is crucial to screen for highly relevant phenotype-genotype association pairs. Based on the single genotype-phenotype association test and a pathway enrichment analysis, we propose a Metabolite-pathway-based Phenome-Wide Association Scan (M-PheWAS) to analyze the key metabolite-SNP pairs in rice and determin...
BACKGROUND Feasibility of genotyping of hundreds and thousands of single nucleotide polymorphisms (SNPs) in thousands of study subjects have triggered the need for fast, powerful, and reliable methods for genome-wide association analysis. Here we consider a situation when study participants are genetically related (e.g. due to systematic sampling of families or because a study was performed in ...
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