1 The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, 2 Institute of Medical Engineering and Science, Department of Biological Engineering, and Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, 3 Department of Biomedical Engineering and Center of Synthetic Biology, Boston University, Bosto...

We identified 255 loci across the human genome that contain genomic imbalances among unrelated individuals. Twenty-four variants are present in 410% of the individuals that we examined. Half of these regions overlap with genes, and many coincide with segmental duplications or gaps in the human genome assembly. This previously unappreciated heterogeneity may underlie certain human phenotypic var...

DNA methylation is a crucial epigenetic mark in mammalian development, genomic imprinting, X-inactivation, chromosomal stability and suppressing parasitic DNA elements. DNA methylation in neurons has also been suggested to play important roles for mammalian neuronal functions, and learning and memory. In this review, we first summarize recent discoveries and fundamental principles of DNA modifi...

The prevalence of different antimicrobial resistance profiles and variants of the Salmonella genomic island 1 (SGI1) was reported for Salmonella enterica serovar Typhimurium DT104 strains isolated from patients in Denmark. Variation in antimicrobial resistance and corresponding changes of SGI1 were shown among isolates from a foodborne outbreak.

....................................................................................................... 89 Introduction ....................................................................................................... 90 Results ........................................................................................................ 92 Discussion ..............................................