Background: Trauma and surgery may be complicated by pulmonary dysfunction, acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), but the mechanisms are incompletely understood. Methods: We evaluated lung capillary protein permeability non-invasively with help of the 67Gatransferrin pulmonary leak index (PLI) technique and extravascular lung water (EVLW) by the transpulmonary ...

MicroRNAs (miRNAs) are small non-coding RNA transcripts approximately 20 nucleotides in length that regulate expression of protein-coding genes via complementary binding mechanisms. The last decade has seen an exponential increase of publications on miRNAs, ranging from every aspect of basic cancer biology to diagnostic and therapeutic explorations. In this review, we summarize findings of miRN...

Accumulating evidence supports that the inflammatory milieu plays a key role in the initiation and progression of epithelial cancer, the most characteristic example being that of ulcerative colitis which is associated with increased risk of colonic adenocarcinoma. Other less frequent and studied inflammatory lesions include asbestos-induced cellular damages, oral lichen planus (premalignant les...