The popular Genome-wide Complex Trait Analysis (GCTA) software uses the random-effects models for estimating the narrow-sense heritability based on GWAS data of unrelated individuals without knowing and identifying the causal loci. Many methods have since extended this approach to various situations. However, since the proportion of causal loci among the variants is typically very small and GCT...

Abstract An increased divergence in characters between species secondary contact can be shaped by selection against competition for a common resource (ecological character displacement, ECD) or maladapted hybridization (reproductive RCD). These selective pressures act incipient (reinforcement) well-separated that already completed the speciation process, but still hybridize and produce hybrids....

Genotyping errors are known to influence the power of both family-based and case-control studies in the genetics of complex disease. Estimating genotyping error rate in a given dataset can be complex, but when family information is available error rates can be inferred from the patterns of Mendelian inheritance between parents and offspring. I introduce a novel likelihood-based method for calcu...

Growth-associated protein 43 (GAP43), a synaptic involved in axonal growth and plasticity, is implicated the pathophysiology of autism spectrum disorder (ASD) schizophrenia. To examine role rare GAP43 variants genetic etiology ASD schizophrenia Japanese population, we performed resequencing association analysis. First, resequenced coding region 295 patients, 323 patients 304 controls. Second, g...

the aim of this study was to investigate the prevalence of hepatitis b virus (hbv) genotypes in isparta, southwest of turkey, as well as the clinical features and transmission route for patients with hbv infections. methods: patients (n = 135) with hbv infection were included in the study. epidemiological and clinical data were obtained. hbv genotypes were determined with a pres2 epitope elisa ...

Dense marker genotypes allow the construction of the realized relationship matrix between individuals, with elements the realized proportion of the genome that is identical by descent (IBD) between pairs of individuals. In this paper, we demonstrate that by replacing the average relationship matrix derived from pedigree with the realized relationship matrix in best linear unbiased prediction (B...

Selective recombinant genotyping (SRG) is a three-stage procedure for high-resolution mapping of a QTL that has previously been mapped to a known confidence interval (target C.I.). In stage 1, a large mapping population is accessed and phenotyped, and a proportion, P, of the high and low tails is selected. In stage 2, the selected individuals are genotyped for a pair of markers flanking the tar...

an f2 japanese quail population was developed by crossing two strains (wild and white) to map quantitative trait loci (qtl) for performance and carcass traits. a total of 472 f2 birds were reared and slaughtered at 42 days of age. performance and carcass traits were measured on all of the f2 individuals. parental (p0), f1 and f2 individuals were genotyped with 3 microsatellites from quail chrom...