Aminoglycoside antibiotics and gentamicin (GN), in particular, are still widely used clinical practice. It is a well-known fact that GN causes nephrotoxicity, redox disturbances discussed as factor its side effects. Recently, new type of cell oxidative death, named ferroptosis, was discovered; it associated with iron accumulation the cell, glutathione (GSH) depletion inactivation peroxidase-4 (...

Background: An ear infection, can be classified into otitis externs and media, this affects all age groups especially infants young. This infection associate with pathogenic microorganism type, frequent antibiotic uses, health care age. The most common bacteria of the are Pseudomonas spp. Antibiotic resistance represents a serious threat to humans. Methods: 48 swabs were collected through use w...

BACKGROUND Gut microbiota play a major role in digestion and energy conversion of nutrients. Antibiotics, such as avoparcin (a vancomycin analogue), and probiotics, such as Lactobacillus species, have been used to increase weight in farm animals. We tested the effect of antibiotics given for infective endocarditis (IE) on weight gain (WG). METHODOLOGY/PRINCIPAL FINDINGS Forty-eight adults wit...

Newly hatched chickens were allowed to survive 6, 10, 15, and 20 weeks after 10 days of gentamycin sulfate treatment. Ultrastructural studies of hair cells and nerve terminals in the auditory receptor organ, the basilar papilla, were carried out with transmission and scanning electron microscopes. Attention was paid to absolute sensory cell (hair cell) numbers, stereocilia maturity and orientat...

Accelerated medial calcification is a major cause of premature cardiovascular mortality in patients with chronic kidney disease (CKD). Evidence suggests that extracellular concentration of Ca2+ and vascular smooth muscle cells may play a pivotal role in the pathogenesis of vascular calcification. The calcium-sensing receptor (CaSR) is a G protein-coupled receptor that is expressed in a range of...

Seventy-one blood cultures were taken from 26 suspected cases of bacterial endocarditis. Antibiotic sensitivity pattern was determined in 29 positive cultures. Gentamycin was found to be the most effective. Cloxacillin, chloramphenic.o1,vibramycin, tetracycline, erythromycin were next in order (J PMA 33 87,1983).

We report a case of chronic calcaneal osteomyelitis in a diabetic patient who was successfully treated with radical debridement and gentamycin-impregnated calcium phosphate cement. At 1.5-year follow-up, the patient could walk without any assistance. Calcium phosphate cement is an effective local antibiotic delivery system and a biocompatible material for filling the debrided space to facilitat...