Intradiscal injections have been used for many years in the treatment of chronic pain. These injections consisted of many substances providing variable pain relief from discogenic pain. Following an intradiscal dextrose injection series, a physically active patient developed superior and inferior lumbar endplate fractures, producing a drastic increase in pain. The pathology of endplate fracture...

An electron microscopic study on the fine structural differences of motor endplates among the red, white and intermediate muscle fibers of the rat intercostal muscles was made and the following results were obtained. 1. In the motor endplate of the red fiber, the junctional folds were poorly developed and their number was small. 2. In the motor endplate of the white fiber, the junctional folds ...

Endplate separations are defined as the presence of a space between the hyaline cartilage and the cortical bone of the adjacent vertebral body. This study evaluates endplate separations from the vertebral body and intervertebral discs and verifies if endplate separation is related to age and the spinal level. Groups were formed based on age (20-40 and 41-85 years old) and the vertebral segment ...

Expression of adult-type nicotinic acetylcholine receptors at the neuromuscular junction is thought to result from selective induction of their genes in endplate-associated nuclei due to local neurotrophic control. However, denervation studies indicate that endplate-specific expression can be maintained in the absence of the nerve. We investigated the role played by the basal lamina in this exp...

Multiphoton imaging and Raman spectroscopy reveal chemistry micro-structure of the bovine vertebral endplate.

PURPOSE To evaluate position and function of antiglaucomatous Ahmed and Molteno shunts using magnetic resonance imaging with head and surface coils. METHODS Eight patients (5 males) with shunt implants were included, 4 with Ahmed (FP-7) and 4 with Molteno (s1, single plated). All patients were operated at least 6 months before imaging. In 3 cases (2 with Molteno and 1 with Ahmed shunt), the i...

INTRODUCTION: The intervertebral disc undergoes extensive age related degenerative changes. The mechanism for disc degeneration is multifactorial and many studies have proposed that decreased nutrition to the disc is a major contributor to the degeneration process. Because the adult disc nucleus is avascular, the only sources of nutrition are diffusion from the blood vessels of the annulus and ...

STUDY DESIGN Retrospective study. PURPOSE To investigate the relation between the progression of kyphotic deformity and magnetic resonance imaging (MRI) findings in conservatively treated stable thoracolumbar fractures. OVERVIEW OF LITERATURE When treated conservatively, excessive progression of kyphotic deformity and vertebral compression can emerge during follow-up. We sought to identify ...

The in vivo degradation of endplate acetylcholine receptors was investigated in mice treated daily with IgG from 10 myasthenia gravis patients. Four preparations increased the rate of degradation. The number of endplate acetylcholine receptors after 7 days of IgG treatment was greater than that predicted on the basis of the increased degradation rate, suggesting a compensatory increase in recep...

BACKGROUND CONTEXT The annulus-endplate anchorage system performs a critical role in the disc, creating a strong structural link between the compliant annulus and the rigid vertebrae. Endplate failure is thought to be associated with disc herniation, a recent study indicating that this failure mode occurs more frequently than annular rupture. PURPOSE The aim was to investigate the structural ...