Thyroid hormone receptors (TRs) are ligand-gated transcription factors. Recently, many coregulator proteins have been identified that interact with steroid/TRs and are required for the activation or repression of hormone sensitive genes. We tested whether steroid receptor coactivator-1 (SRC-1) and nuclear corepressor (N-CoR) expression is altered by hypothyroidism in rat brains on gestational d...

OBJECTIVES Evaluate the management of hypothyroidism in fertile-aged and pregnant women and compare these practices to the recommendations of the Brazilian Society of Endocrinology and Metabolism (SBEM) and the Latin American Thyroid Society, published in 2013. MATERIALS AND METHODS In the first trimester of 2014, SBEM made available to all members an electronic questionnaire based on clinica...

Objectives. Diabetes mellitus (DM) and hypothyroidism are each associated with increased rate of pregnancy complications. However, their combined morbidity during gestation is poorly studied. Therefore, the aims of this study were to determine the prevalence of the combined morbidity of DM & hypothyroidism and whether it is associated with adverse maternal and neonatal outcome. Study design. Th...

AIM To determine the frequency of hypothyroidism in women with recurrent pregnancy loss in first trimester in the Indian population. SETTINGS AND DESIGN The study included 163 non-pregnant women with recurrent pregnancy loss in a gestational age up to <or=12 weeks verified by a pregnancy test or ultrasonography, and a total of 170 age matched women with at least one successful pregnancy and n...

Objective: To examine the thyroid status and adequacy of thyroxine replacement at the first antenatal visit in Hong Kong women with a known history of hypothyroidism prior to pregnancy. Methods: Data were obtained from an electronic database, which registered all medical diseases complicating pregnancy among women attending the high-risk obstetric clinic in a teaching hospital between 1 April 2...

Aim: The most common metabolic disorder during pregnancy is gestational diabetes mellitus (GDM). GDM can occur in anywhere between 1.7 and 11.6 percent of people. In hypothyroidism, the rates glucose oxidation glycogen synthesis are reduced, peripheral tissues' consumption also delayed. Patients with subclinical overt hypothyroidism develop insulin resistance because unable to adequately mainta...

To determine the validity of a repeat thyroid function test for preterm infants, and to investigate factors that influence thyroid function of preterm infants, thyroid functions of 105 infants born at <32 weeks' gestational age were evaluated. Initial serum free thyroxine (fT4) and thyrotropin (TSH) levels were measured during the first 10 days of life, and repeated tests were performed more th...

OBJECTIVES Thyroid hormones play an essential role in fetal growth and maternal hypo-thyroidism which leads to cardiovascular deficiency in their offspring. Considering this, we intended to investigate the impact of gestational hypothyroidism on offspring vascular contractibility and possible underlying mechanisms. MATERIALS AND METHODS Hypothyroidism was induced in female rats by administrat...

Background: Cerebral venous sinus thrombosis (CVT) is a rare neurological emergency that occurs more often among women during pregnancy and puerperium than the general population. Isolated cranial nerve palsies are uncommon in pregnant abducens palsy extremely rare. Methods: We report case of woman with hypothyroidism gestational diabetes mellitus at 32+3 weeks gestation who was diagnosed hyper...

Free triiodothyronine (FT3) has rarely been studied in neonates, primarily because of obvious problems in obtaining serum samples from neonates for research purposes. We adapted an analog radioimmunoassay for measuring FT3 in dried blood samples and used it to assay 361 samples selected from those collected for the screening for neonatal hypothyroidism. The mean FT3 concentration in healthy neo...