We report a plasma cell neoplasm in conjunction with a glioblastoma multiforme (GBM) of the conus medullaris in a 42-year-old man. Glioblastoma is a World Health Organization (WHO) grade IV neoplasm that requires surgical intervention, radiation, and possibly chemotherapy. Astrocytomas of the spinal cord are rare neoplasms, with intramedullary glioblastomas comprising only 1% to 3%. Plasma cell...

Fungal metabolites continue to show promise as a viable class of anticancer agents. In the present study, we investigated the efficacy of the fungal metabolite, fusarochromanone (FC101), for its antitumor activities in glioblastomas, which have a median survival of less than two years and a poor clinical response to surgical resection, radiation therapy and chemotherapy. Using clinically applic...

central giant cell granuloma (cgcg), formerly called giant cell reparative granuloma, is a non-neoplastic proliferative lesion of unknown etiology. it occurs most commonly in the mandible. the case reported here resembled a wide variety of conditions that led to a misdiagnosis both on clinical and radiographic examinations but was histopathologically diagnosed as cgcg. we describe a case of cgc...

The neurotrophic hepatocyte growth factor attenuates CD8+ cytotoxic T-lymphocyte activity BENKHOUCHA, Mahdia, et al. BENKHOUCHA, Mahdia, et al. The neurotrophic hepatocyte growth factor attenuates CD8+ cytotoxic T-lymphocyte activity. CD40/CD40L expression correlates with the survival of patients with glioblastomas and an augmentation in CD40 signaling enhances the efficacy of vaccinations and ...

Abstract The glioblastoma microenvironment is an immunosuppressive barrier to therapeutic innovation. We hypothesized intratumor convection enhanced delivery (CED) of gene therapy vectors could reprogram the immune and elucidate vulnerabilities. To test this, SB28 or GL261 allografts were implanted into immunocompetent mice treated with CED attenuated adeno-associated virus 9 (AAV9) encoding ex...

Background:  Giant cell tumor of tendon sheath (GCTTS) is often thought of as a volar finger mass. We hypothesized that GCTTS are equally common on the dorsal and volar aspects of the hand. In addition, we hypothesized that there are no factors associated with the location (volar versus dorsal) and largest measured dimension of a GCTTS.  Methods:  A total of 126 patients with a pathological dia...

Glioblastomas in adults are highly heterogeneous tumors that can develop throughout the brain. To date no predictive-location marker has been identified. We previously derived two glioblastoma cell lines from cortical and periventricular locations and demonstrated distinct transcriptomic profiles. Based on these preliminary results, the aim of this study was to correlate glioblastoma locations ...

Objective: The purpose of this study was to retrospectively analyze the demographic characteristics of patients with central peripheral giant cell granulomas (CGCGs) / (PGCGs) an Iranian population. Methods: In this 38-year retrospective study, the data were obtained from records of 1019 patients with CGCG and PGCG of the jaws referred to the Department of Oral and Maxillofacial, Pathology, ...

To evaluate possible roles of matrix metalloproteinase (MMP)-1, -2, tissue inhibitor of metalloproteinase (TIMP)-1, -2 and membrane-type-1 matrix metalloproteinase (MT1-MMP) in invasion of human gliomas, expressions of these proteins were investigated in ten cases of human glioma and two meningioma tissues and eight human glioma cell lines. In gelatin zymography, MMP-2 activities of glioblastom...

background:  giant cell tumor of tendon sheath (gctts) is often thought of as a volar finger mass. we hypothesized that gctts are equally common on the dorsal and volar aspects of the hand. in addition, we hypothesized that there are no factors associated with the location (volar versus dorsal) and largest measured dimension of a gctts.  methods:  a total of 126 patients with a pathological dia...