Large, atypical peripheral ossifying fibromas are known as giant peripheral ossifying fibromas.  These lesions have often been associated with heterogeneous clinical and radiographic characteristics subsequently leading to their misdiagnosis.  Biopsies have been the gold standard for the diagnosis of such lesions.  This study reports on an acute presentation of giant peripheral ossifying fibrom...

two rare cases of extra-articular diffuse variant giant cell tumor of the tendon sheath are presented, at the elbow of a 68-year-old female and the foot of a 56-year-old male. both patients presented with a palpable masses and marginal excision was performed; histological sections confirmed the diagnosis of extra-articular giant cell tumor. no adjuvant therapy was administered. at the last foll...

this case report describes a 59-year-old woman with a giant basal cell carcinoma on the face neglected for 11 years. surgical resection of the lesion resulted in a 13 × 11 cm defect. issues regarding the adequately safe surgical margins and the management of the resultant defect through modern wound dressing technologies are discussed. keywords : giant basal cell carcinoma, modern dressing, gel...

a 28-year-old man presented with a chest radiograph strongly suggestive for cardiomegaly. although he did not consent any hemodynamic studies, cardiomegaly was ruled out on the basis of the clinical course. computed tomography showed the existence of a large mass in both sides of the heart and in both lower hemithoraces. the tumor was resected by anterior mediastinotomy; it was weighted 2100 g ...

Giant cell tumor (GCT) is a benign primary bone neoplasm that usually occurre in the long bones. The skull is affected in only 1% of cases, predominantly in the sphenoid and temporal bones. Maxillary sinus involvement is exceedingly rare. The case is a 26 year-old man presented with history of gradually increasing swelling in the right side of face without any history of trauma or systemic diso...

Introduction: It is well-recognized that cells of the monocyte/macrophage lineage are capable of fusion to form multinucleated giant cells (MGCs). The presence of multinucleated giant cells on FNAC smears of breast lumps have been described only sporadically in the literature. As this is a common specimen in Cytopathology, knowledge of frequency of this variation can be valuable to cytopatholog...

STATEMENT OF THE PROBLEM Peripheral and central giant cell granuloma are two common benign lesions of the oral cavity. In spite of histopathological similarities, they have different clinical behaviors. Cathepsin D is a lysosomal enzyme which has different functions on the basis of protein and applied peptide cleavage. PURPOSE This research aimed to evaluate and compare the expression level o...

Introduction: Multinucleated giant cells are often encountered in oral lesions. An understanding of the histogenesis of these giant cells can give us an insight on the pathologic process in progress. Traditional classifications have placed little importance on the type or histogenesis of multinucleated giant cells in grouping these lesions. Objectives: (a) To classify giant cell lesions based o...