Malignant phyllodes tumor is a rare breast malignancy with sarcomatous overgrowth and with limited effective treatment options for recurrent and metastatic cases. Recent clinical trials indicated a potential for anti-angiogenic, anti-EGFR and immunotherapeutic approaches for patients with sarcomas, which led us to investigate these and other targetable pathways in malignant phyllodes tumor of t...

BACKGROUND Phyllodes tumors are rare fibroepithelial tumors accounting for less than 1 % of all breast neoplasms. They are malignant in 20 % of cases. Only a few cases of malignant phyllodes tumors metastatic to bone have been reported. CASE PRESENTATION Case 1: A 40 year-old white woman presented with three-week history of pain and functional impairment of the left lower limb. Her clinical p...

BACKGROUND Phyllodes tumor is a rare breast mass. Most phyllodes tumors are benign, but occasionally some show malignancy. Even if the tumors are benign, they can easily show recurrence. CASE PRESENTATION We report a case of a 48-year-old Asian woman, who had previously undergone a tumorectomy of her left breast 12 years before, with a pathological diagnosis of fibroadenoma. Five years after ...

Introduction. Phyllodes tumors are rare fibroepithelial tumors which constitute less than 1% of all known breast neoplasms. The importance of recognizing these tumors lies in the need to differentiate them from fibroadenomas and other benign breast lesions to avoid inappropriate surgical management. We report a case of large phyllodes tumor which caused rupture of the breast and presented as an...

Malignant phyllodes tumors are relatively rare, accounting for 0.3 to 0.9% of all tumors of the breast. This tumor metastasizes approximately 20% of the cases depending upon the histologic behavior (1). The most common site of metastasis is the lung (1). Of all possible organs, metastasis to the skeletal muscle is relatively unusual. Moreover, imaging findings of metastasis to the skeletal musc...

Phyllodes tumors are large breast tumors representing only 1% of breast neoplasms and are rarely seen in young women. Histologically, phyllodes tumors are classified as benign, borderline, or malignant based on the characteristics of the stroma. Although wide local excision is recommended for the treatment modality, the reoccurrence rate after surgical excision varies between 36% and 65%, with ...

Los Tumores Phyllodes son patologías mamarias poco frecuentes con histología estromal y epitelial, dividiéndose en benignos, borderline o malignos. Se desarrollan más frecuentemente pacientes entre los 35-55 años de edad, representando el 0.3%-1% tumores primarios la mama. Clínicamente se caracterizan por aparición una masa indolora, firme, multilobulada crecimiento rápido que puede lle...

giant cell carcinoma of the endometrium is a rare and an aggressive tumor that should be distinguished from other endometrial tumors with a prominent giant cell component, including trophoblastic tumors, certain primary sarcomas, and malignant mixed müllerian tumors. at present, cumulative data on this rare histological variant is limited and the prognostic significance of the presence and the ...

CONTEXT Phyllodes tumors are rare fibro-epithelial lesions which make up less than 1% of all breast neoplasms. After curative surgery, distant metastases may occur without local recurrence; the typical sites of the metastases being the lungs and the bones. Endoscopic ultrasound (EUS) and EUS-guided fine needle aspiration (EUS-FNA) has emerged as the leading modalities for the evaluation of panc...