نتایج جستجو برای: gli1

تعداد نتایج: 1131  

2016
Xuebing Li Xuexia Zhou Yaguang Fan Yalong Zhang Lingling Zu Feng Yao Qinghua Zhou

Over-expression of Gli1 is very common in lung cancer. However, the underlying molecular mechanism remains largely unknown. Here, using mass spectrum, we have identified WW45 as a binding partner of Gli1. WW45 interacted with Gli1, promoted its ubiquitination and inhibited the expression of its target genes. In the functional studies, WW45 inhibited the growth and migration of lung cancer cells...

2016
Ruowen Zhang Jiahui Wu Sylvain Ferrandon Katie J. Glowacki Janet A. Houghton

The GLI genes are transcription factors and in cancers are oncogenes, aberrantly and constitutively activated. GANT61, a specific GLI inhibitor, has induced extensive cytotoxicity in human models of colon cancer. The FOXM1 promoter was determined to be a transcriptional target of GLI1. In HT29 cells, inhibition of GLI1 binding at the GLI consensus sequence by GANT61 led to inhibited binding of ...

2016
Alain Mauviel Thomas Jefferson Natalia Riobo Barbara Stecca Tara L. Hogenson Martin E. Fernandez-Zapico

Aberrant activation of the transcription factor GLI1, a central effector of the Hedgehog (HH) pathway, is associated with several malignancies, including pancreatic ductal adenocarcinoma (PDAC), one of most deadly human cancers. GLI1 has been described as an oncogene in PDAC, making it a promising target for drug therapy. Surprisingly, clinical trials targeting HH/GLI1 axis in advanced PDAC wer...

2014
Alla Piirsoo Lagle Kasak Mari-Liis Kauts Mart Loog Kairit Tints Piia Uusen Toomas Neuman Marko Piirsoo

Observations that Glioma-associated transcription factors Gli1 and Gli2 (Gli1/2), executers of the Sonic Hedgehog (Shh) signaling pathway and targets of the Transforming Growth Factor β (TGF-β) signaling axis, are involved in numerous developmental and pathological processes unveil them as attractive pharmaceutical targets. Unc-51-like serine/threonine kinase Ulk3 has been suggested to play kin...

2015
Vikas Chandra Tapojyoti Das Puneet Gulati Nidhan K. Biswas Sarang Rote Uttara Chatterjee Samarendra N. Ghosh Sumit Deb Suniti K. Saha Anup K. Chowdhury Subhashish Ghosh Charles M. Rudin Ankur Mukherjee Analabha Basu Surajit Dhara

Hedgehog (Hh) signaling pathway is a valid therapeutic target in a wide range of malignancies. We focus here on glioblastoma multiforme (GBM), a lethal malignancy of the central nervous system (CNS). By analyzing RNA-sequencing based transcriptomics data on 149 clinical cases of TCGA-GBM database we show here a strong correlation (r = 0.7) between GLI1 and PTCH1 mRNA expression--as a hallmark o...

2014
Masashi Ishikawa Makoto Sonobe Naoto Imamura Terumasa Sowa Kei Shikuma Hiroshi Date

BACKGROUND The hedgehog (Hh) signaling pathway is aberrantly activated in various cancers. Expression of the GLI family of genes, which encode for transcriptional factors of the Hh pathway, has not been fully assessed in clinical samples of advanced lung adenocarcinoma. In this study, we retrospectively evaluated the expression of the GLI family of genes in advanced stage lung adenocarcinoma sa...

Journal: :Development 1998
A Ruiz i Altaba

Within the developing vertebrate nervous system, it is not known how progenitor cells interpret the positional information provided by inducing signals or how the domains in which distinct groups of neural cells differentiate are defined. Gli proteins may be involved in these processes. In the frog neural plate, we have previously shown that the zinc finger transcription factor Gli1 is expresse...

2011
Sandeep K. Nadendla Allon Hazan Matt Ward Lisa J. Harper Karwan Moutasim Lucia S. Bianchi Mahmoud Naase Lucy Ghali Gareth J. Thomas David M. Prowse Michael P. Philpott Graham W. Neill

The GLI (GLI1/GLI2) transcription factors have been implicated in the development and progression of prostate cancer although our understanding of how they actually contribute to the biology of these common tumours is limited. We observed that GLI reporter activity was higher in normal (PNT-2) and tumourigenic (DU145 and PC-3) androgen-independent cells compared to androgen-dependent LNCaP pros...

2018
Eloise Mastrangelo Mario Milani

GLI1 is a transcriptional regulator involved in the development of different types of cancer. GLI1 transcriptional activity is regulated within the Hedgehog pathway (canonical activity), but can also be controlled independently (non-canonical activity) in the context of other signaling pathways. Experimental evidences show GLI1 involvement in both small- and non-small-cell lung cancers. Direct ...

2016
Ashley J. Williamson Michelle E. Doscas Jin Ye Katherine B. Heiden Mingzhao Xing Yi Li Richard A. Prinz Xiulong Xu

The sonic hedgehog (Shh) pathway is highly activated in thyroid neoplasms and promotes thyroid cancer stem-like cell phenotype, but whether the Shh pathway regulates thyroid tumor cell motility and invasiveness remains unknown. Here, we report that the motility and invasiveness of two anaplastic thyroid tumor cell lines, KAT-18 and SW1736, were inhibited by two inhibitors of the Shh pathway (cy...

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